Traumatic brain injury (TBI) is described by a disruption in the normal function of the brain due to an injury following a trauma, which can potentially cause severe physical, cognitive, and emotional impairment. The use of human stem cells and self-assembling peptide scaffolds suggest huge potential for application in the treatment of TBI. In the present study, we surveyed the beneficial effec...

Freeze-drying is one of the most used methods for preparing scaffolds and is very sensitive to the material and operational parameters such as nucleation temperature, thermal properties of the mold, cooling rate, set freezing point, and slurry height. In the present study, a Finite Element Method (FEM) based code was developed to investigate the effects of such parameters and to eventually ...

Kerusakan tulang yang akan terjadi di Indonesia pada golongan tenaga kerja sebesar 67,76% berupa penurunan massa dan 28,58% gangguan kepadatan tulang. Scaffold dapat dijadikan sebagai alternatif dari perawatan penyembuhan kerusakan dalam bentuk perancah berpori 3D. menyediakan lingkungan sesuai untuk regenerasi jaringan Biomaterial keramik bahan dasar cocok scaffold karena karakteristiknya, nam...

Several challenges persist when attempting to utilize decellularized tissue as a scaffold for vascular tissue engineering. Namely: poor cell infiltration/migration, excessive culture times associated with repopulating the scaffolds, and the achievement of a quiescent medial layer. In an attempt to create an optimum vascular scaffold, we customized the properties of decellularized porcine caroti...

The cell signaling molecule MEK kinase 2 (MEKK2) is a key upstream regulator of MAPK activity that regulates numerous cellular functions, but the mechanisms that control MEKK2 activity are not well understood. Recently, we reported that MEKK2 both binds and promotes ubiquitylation of the scaffold protein paxillin, and thereby modulates the composition of adhesion complexes. In this study, we ha...

Background: The prevalence of tooth extraction was 7.29% according to RISKESDAS 2018. Post-tooth will cause injury and bone resorption. Scaffold material combination hydroxyapatite gypsum puger (HAGP) aloe vera (AV) can be used for preservation socket. Objective: To analyze fibroblast type 1 collagen cells in the socket after being induction by a scaffold vera. Materials Methods: Making vera, d...

The selective autophagy receptors Atg19 and Atg32 interact with two proteins of the core autophagic machinery: the scaffold protein Atg11 and the ubiquitin-like protein Atg8. We found that the Pichia pastoris pexophagy receptor, Atg30, also interacts with Atg8. Both Atg30 and Atg32 interactions are regulated by phosphorylation close to Atg8-interaction motifs. Extending this finding to Saccharo...

The structure of an osteochondral biphasic scaffold is required to mimic native tissue, which owns a calcified layer associated with mechanical and separation function. The two phases of biphasic scaffold should possess efficient integration to provide chondrocytes and osteocytes with an independent living environment. In this study, a novel biphasic scaffold composed of a bony phase, chondral ...