Abstract The human proteome is enriched in proteins that do not fold into a stable 3D structure. These intrinsically disordered (IDPs) spontaneously fluctuate between large number of configurations their native form. Remarkably, the disorder does lead to dysfunction as with denatured folded proteins. In fact, unlike proteins, recent evidence strongly suggests multiple biological functions stem ...

Machine learning (ML) empowers biomedical systems with the capability to optimize their performance through modeling of available data extremely well, without using strong assumptions about modeled system. Especially in nano-scale biosystems, where generated sets are too vast and complex mentally parse computational assist, ML is instrumental analyzing extracting new insights, accelerating mate...