Chitosan is one of the most used polysaccharides in the design of drug delivery strategies for administration of either biomacromolecules or low molecular weight drugs. For these purposes, it is frequently used as matrix forming material in both nano and micron-sized particles. In addition to its interesting physicochemical and biopharmaceutical properties, which include high mucoadhesion and a...

in recent years, utilization of chitosan /tripolyphosphate nanoparticles has been considered greatly as protein delivery vehicles. effects of a variety of factors on final characteristics of nanoparticles have been studied by many investigators. although, the objective of this study was to achieve smaller chitosan nano carriers via changing fabrication parameters such as ph and temperature and ...

Non-viral gene carriers composed of biodegradable polymers or lipids have been considered as a safer alternative for gene carriers over viral vectors. We have developed multi-functional nano-micelles for both drug and gene delivery application. Polyethyleneimine (PEI) was modified by grafting stearic acid (SA) and formulated to polymeric micelles (PEI-SA) with positive surface charge for gene a...

Graphene quantum dots (GQDs) exhibit excellent opto-electronic properties along with fine-tunable structure and surface properties, which have made them versatile drug carriers. Here GQDs were prepared using carbon black as precursor through oxidation ball-milling. The found to be nano-sized, oxidized, water-soluble highly fluorescent. extremely biocompatible against the tested cell lines namel...

Cosmetics attract most age groups from teenagers to old age. Cosmetic goods now contain a variety of nanoparticle and nanomaterial types. Nano cosmeceuticals have changed the era cosmetics as they advanced delivery mechanisms with task specifications. They are used in nail, hair, lip, skin care products by cosmetic giants including Estee Lauder, L’oreal, Nivea, Zelens, Derma Swiss, etc., patent...

in this study, geometrical optimizations of clonidine drug were carried out with the hf/6-31g basissets .then, drug was put covalently to carbon nanocone with (5, 1) structure and a length of 150a. weuse chem office software and hyper chem at the end data will be presented as tables and figs.simulation was done in mm+, amber and opls force fields by monte carlo method. threeimportant energy par...

Nano-delivery systems represent one of the most studied fields, thanks to associated improvement in treatment human diseases. The functionality nanostructures is a crucial point, which effectiveness nanodrugs depends on. A hybrid approach strategy using synthetic nanoparticles (NPs) and erythrocytes offers an optimal blend natural materials. This, turn, allows medical practitioners exploit comb...

Photo-based diagnosis and treatment methods are gaining prominence due to increased spatial imaging resolution, minimally invasive modalities involved as well as localized treatment. Recently, nanoparticles (NPs) have been developed and used in photo-based therapeutic applications. While some nanomaterials have inherent photo-based imaging capabilities, others including polymeric NPs act as nan...

Abstract Extracellular vesicles (EVs) are nano-sized derived from cells that transport biomaterials between through biofluids. Due to their biological role and components, they considered as potential drug carriers for diagnostic applications. Today's advanced nanotechnology enables single-particle-level analysis was difficult in the past due its small size below diffraction limit. Single EV re...