A disintegrin and metalloproteinase domain-containing protein 12 (ADAM12) belongs to the ADAM family of transmembrane proteins. Via proteolysis, cell adhesion, cell-cell fusion, cell-matrix interaction and membrane protein shedding, ADAM proteins are involved in normal brain development, and also in cancer genesis and progression, and in inflammation. Therefore, neurobiological research focusin...

One new cyclic hexapeptide named rubipodanin A (1), which is the first identified natural N-desmonomethyl Rubiaceae-type cyclopeptide, together with six known Rubiaceae-type cyclopeptides (2-7) were obtained using the TLC cyclopeptide protosite detection method with ninhydrin from the roots and rhizomes of Rubia podantha. The cyclopeptide structures were elucidated by extensive spectroscopic an...

The circumference of a graph is the length of its longest cycles. A result of Jackson and Wormald implies that the circumference of a 3-connected claw-free graph is at least 1 2 n150 . In this paper we improve this lower bound to Ω(n3 ), and our proof implies a polynomial time algorithm for finding a cycle of such length. Bondy and Simonovits showed that Θ(n9 ) is an upper bound. Partially supp...

The x-ray structure of a complex of sialic acid (Neu5Ac) with neuraminidase N9 subtype from A/tern/Australia/G70C/75 influenza virus at 4 degrees C has revealed the location of a second Neu5Ac binding site on the surface of the enzyme. At 18 degrees C, only the enzyme active site contains bound Neu5Ac. Neu5Ac binds in the second site in the chair conformation in a similar way to which it binds ...

R si fearc^ into the social and psychological effects of *ness on children with such chronic diseases as hrria, diabetes, haemophilia and cystic fibrosis is inclusive; some studies (Olch, 1971; Gayton and Friedar|, 1974) indicate that these children often fall short of Q'r educational potential, but others .(Burton, 1974; J0rmina et al, 1976) suggest that children develop, in ^'n9 strategies, a...

Migration toward pathological area is the first critical step in microglia engagement during the central nervous system (CNS) injury, although the molecular mechanisms underlying microglia mobilization have not been fully understood. Here, we report that hypoxia promotes stromal cell-derived factor-1a (SDF-1a) induced microglia migration by inducing the CXC chemokine receptor 4 (CXCR4) expressi...

We study the link between three seeming-disparate cases of self-avoiding polymers: strongly overlapping multiple chains in dilute solution, chains under spherical confinement, and the onset of semidilute solutions. Our main result is that the free energy for overlapping n chains is independent of chain length and scales as n9/4, slowly crossing over to n3, as n increases. For strongly confined ...