O6-Butylguanine was detected in the urine of rats given the butylating agent N-nitroso-N-butylurea. O6-Butylguanine contents in the 24-h rat urine samples after i.p. doses of 50, 100, and 200 mg/kg N-nitroso-N-butylurea were 1.03 +/- 0.41 (SE), 8.30 +/- 1.70, and 59.53 +/- 6.52 pmol, respectively. This suggests that O6-butylguanine formation in nucleic acids might be repaired in vivo, possibly ...

This study investigated the fate of eight N-nitrosamines during membrane bioreactor (MBR) treatment. The results suggest that biodegradation is mainly responsible for the removal of N-nitrosamines during MBR treatment. Other removal mechanisms were insignificant (e.g. adsorption to sludge) or not expected (e.g. photolysis and volatilization) given the experimental conditions and physicochemical...

N-Nitrosodimethylamine (NDMA) is a probable human carcinogen. This study investigated the root cause of presence NDMA in ranitidine hydrochloride. Forced thermal degradation studies hydrochloride and its inherent impurities (Imps. A, B, C, D, E, F, G, H, I, J, K) listed European United States Pharmacopeias revealed that addition to ranitidine, Imps. I produce at different rates solid or an oily...