A series of benzylamides of isocyclic and heterocyclic acids was synthesized and tested in Anticonvulsant Screening Project (ASP) of Antiepileptic Drug Development Program (ADDP) of NIH. Near all synthesized derivatives of heterocyclic acids showed activity. All obtained derivatives of mono- and bicyclic isocyclic acids were inactive. The power of action of heterocyclic acids derivatives seems ...

In the title mol-ecule, C(24)H(22)N(2), four atoms (N-C-C-N) of the heterocyclic ring, with their attached H atoms, and all atoms of the methyl group, are disordered over two positions; the site-occupancy factor of the major component is 0.713 (6). The major disorder component of the heterocyclic ring adopts a half-chair conformation, with all substituents equatorial. The benzene ring adjacent ...

We prepared a series of imidazolium-substituted uracil-anions which are members of the class of cross-conjugated heterocyclic mesomeric betaines. They are in tautomeric equilibrium with their N-heterocyclic carbenes, uracil-6-yl-imidazol-2-ylidenes. These carbenes can be trapped by reaction with sulfur, selenium, as well as by triethylborane and triphenylborane, respectively. The latter trappin...

The oxidation of 2-iodo-N,N-dialkylanilines with an excess of dimethyldioxirane in acetone affords 2-iodyl-N,N-dialkylaniline oxides, structural features of which are in agreement with the new heterocyclic system of benziodoxazole.

1,1’-Diaminoferrocene (1) was converted to α-aminonitriles fc[NHC(CN)MeR’]2 (fc=1,1’-ferrocenediyl; 2 a: R’=Me, b: R’=Ph, c: R’=tBu) by reaction with ketones MeC(O)R’ in the presence of NaCN/HOAc or diimine fc(N=CPh2)2 (3) condensation Ph2CO. Treatment a–c 3 MeLi furnished fc(NHR)2 (4 R=tBu, 4 R=CMe2Ph, R=CMe2tBu, d: R=CMePh2) after aqueous work-up. The formylative cyclisation a–d fc[(NR)2CH][B...