Combining N-heterocyclic carbenes with gold nanoparticles provides an ultrabright and fragment-free ionization platform for laser-desorption mass spectrometry. In their Research Article (e202219182), David M. Jenkins, Jon P. Camden, co-workers show that NHC-functionalized can “give wings” in the spectrometer, enabling next-generation applications of barcoding, data storage, bioconjugation react...