6,7-Diethoxy-1-[1-(2-methoxyethyl)-2-oxo-1,2-dihydropyridin- 4-yl]naphthalene-2,3-dimethanol [T-440, (1)] is a potential anti-asthmatic agent based on selective phosphodiesterase 4 inhibition. It was necessary for the further evaluation of 1 to develop an efficient synthetic route for 1, especially the construction of the 1-(2-methoxyethyl)-2-pyridone moiety. We examined an N-selective alkylati...

N a z m i A . K a s s a b , S a n a a 0 . A b d A l l a h , a n d S a i d A . E l b a h a i i Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt Z. Naturforsch. 34b, 507-510 (1979); received September 28, 1978 Arylhydrazonorhodanines, Arylhydrazonoisorhodanines, Ring Cleavage, Triazolinones, Alkylation The 5-arylhydrazono derivatives of rhodanine and isorhodanine were su...

The human 8-oxoguanine DNA glycosylase OGG1 is involved in base excision repair (BER), one of several DNA repair mechanisms that may counteract the effects of chemo- and radiation therapy for the treatment of cancer. We envisage that potent inhibitors of OGG1 may be found among the 9-alkyl-8-oxoguanines. Thus we explored synthetic routes to 8-oxoguanines and examined these as OGG1 inhibitors. T...

Correction for 'Photoredox-mediated Minisci C-H alkylation of N-heteroarenes using boronic acids and hypervalent iodine' by Guo-Xing Li et al., Chem. Sci., 2016, DOI: ; 10.1039/c6sc02653b.

A novel class of tartaric acid-derived N-spiro quaternary ammonium salts was synthesised starting from known TADDOLs. These compounds were found to catalyse the asymmetric α-alkylation of glycine Schiff bases with high enantioselectivities and in good yields.