JOHN G. HOHMANN,1 THOMAS H. TEAL,2 DONALD K. CLIFTON,2 JAMES DAVIS,3 VICTOR J. HRUBY,4 GUOXIA HAN,4 AND ROBERT A. STEINER2,5 1Graduate Program in Neurobiology and Behavior, Departments of 2Obstetrics and Gynecology and 5Physiology and Biophysics, University of Washington, Seattle, Washington 98195; 3Amgen Corporation, Thousand Oaks, California 91320; and 4Department of Chemistry, University of ...

Molitoris, Bruce A., Joel M. Weinberg, Manjeri A. Venkatachalam, Richard A. Zager, Karl A. Nath, and Michael S. Goligorsky. Acute renal failure. II. Experimental models of acute renal failure: imperfect but indispensable. Am. J. Physiol. Renal Physiol. 278: F1–F12, 2000.—Acute renal failure (ARF) due to ischemic1 or toxic renal injury, a clinical syndrome traditionally referred to as acute tubu...

Wang, Danzhao, Hideaki Yoshida, Qing Song, Lee Chao, and Julie Chao. Enhanced renal function in bradykinin B2 receptor transgenic mice. Am. J. Physiol. Renal Physiol. 278: F484–F491, 2000.—The tissue kallikrein-kinin system has been recognized as a paracrine and/or autocrine hormonal system that regulates arterial pressure, renal hemodynamics, and electrolyte excretion. We have created a transg...

Kanashiro, Celia A., Kathy L. Cockrell, Barbara T. Alexander, Joey P. Granger, and Raouf A. Khalil. Pregnancy-associated reduction in vascular protein kinase C activity rebounds during inhibition of NO synthesis. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 278: R295– R303, 2000.—Vascular reactivity has been shown to be reduced during pregnancy and to be enhanced during chronic inhibit...

Iwasaki, Hiroaki, Satoru Eguchi, Hikaru Ueno, Fumiaki Marumo, and Yukio Hirata. Mechanical stretch stimulates growth of vascular smooth muscle cells via epidermal growth factor receptor. Am. J. Physiol. Heart Circ. Physiol. 278: H521–H529, 2000.—We have studied whether activation of epidermal growth factor receptor (EGFR) is involved in stretch-induced extracellular signal-regulated kinase 1/2 ...

Sir, Özcan, Nadeem Fazal, Mashkoor A. Choudhry, Richard L. Gamelli, and Mohammed M. Sayeed. Neutrophil depletion prevents intestinal mucosal permeability alterations in burn-injured rats. Am J Physiol Regulatory Integrative Comp Physiol 278: R1224–R1231, 2000.—Cutaneous thermal injury increases intestinal mucosal permeability. The mechanisms of this functional disturbance are not fully understo...

Nekooeian, Ali Akbar, and Catherine C. Y. Pang. Effects of estrogen on venous function in rats with chronic heart failure. Am J Physiol Heart Circ Physiol 278: H1941– H1947, 2000.—The effect of 17b-estradiol on venous function was investigated in ovariectomized rats with heart failure. Rats (50–60 days old) were ovariectomized and implanted with 60-day-release pellets that contain 17b-estradiol...

Takahashi, Yasushi, Christine Roman, Sylvain Chemtob, Mary M. Tse, Emil Lin, Michael A. Heymann, and Ronald I. Clyman. Cyclooxygenase-2 inhibitors constrict the fetal lamb ductus arteriosus both in vitro and in vivo. Am J Physiol Regulatory Integrative Comp Physiol 278: R1496– R1505, 2000.—Nonselective cyclooxygenase (COX) inhibitors are potent tocolytic agents; however, they also have adverse ...

EDWARD J. PULIDO,1 BRIAN D. SHAMES,1 DAVID A. FULLERTON,2 BRETT C. SHERIDAN,1 CRAIG H. SELZMAN,1 FABIA GAMBONI-ROBERTSON,1 DENIS D. BENSARD,3 AND ROBERT C. MCINTYRE, JR1 1Department of Surgery, University of Colorado Health Sciences Center and The Veterans Affairs Hospital, Denver 80262; 3Department of Pediatric Surgery, The Children’s Hospital, Denver, Colorado 80218; and 2Department of Surger...

Jaggar, Jonathan H., Valerie A. Porter, W. Jonathan Lederer, and Mark T. Nelson. Calcium sparks in smooth muscle. Am. J. Physiol. Cell Physiol. 278: C235–C256, 2000.—Local intracellular Ca21 transients, termed Ca21 sparks, are caused by the coordinated opening of a cluster of ryanodine-sensitive Ca21 release channels in the sarcoplasmic reticulum of smooth muscle cells. Ca21 sparks are activate...