Chisholm, Jeffrey W., Patrick Nation, Peter J. Dolphin, and Luis B. Agellon. High plasma cholesterol in drug-induced cholestasis is associated with enhanced hepatic cholesterol synthesis. Am. J. Physiol. 276 (Gastrointest. Liver Physiol. 39): G1165–G1173, 1999.—In a-naphthylisothiocyanate-treated mice, plasma phospholipid (PL) levels were elevated 10and 13-fold at 48 and 168 h, respectively, wh...

KChIPs coassemble with pore-forming Kv4 a subunits to form a native complex in the brain and heart and regulate the expression and gating properties of Kv4 K1 channels, but the mechanisms underlying these processes are unknown. Here we report a co-crystal structure of the complex of human Kv4.3 N-terminus and KChIP1 at a 3.2-Å resolution. The structure reveals a unique clamping action of the co...

Results: Mean age of the children in the obese group (n= 27) was 8.1 ± 2.6 while that in the non-obese group (n= 71) was 8.6 ± 2.9 (p= 0.41). Asthma symptom score in obese and non-obese groups were not significantly different (p= 0.73). Children in the obese group had lower ACQ scores when compared to the non-obese group (1.2 ± 0.9 vs 1.7 ± 1.0, p= 0.04) however this significance was lost when ...

J. M. ANDREWS,1 H. NATHAN,2 C. H. MALBERT,3 M. A. M. T. VERHAGEN,4 M. GABB,5 G. S. HEBBARD,1 D. KILPATRICK,6 S. MACDONALD,2 C. K. RAYNER,1 S. DORAN,1 T. OMARI,7 E. O’YOUNG,2 C. FRISBY,2 R. J. FRASER,1 M. SCHOEMAN,2 M. HOROWITZ,1 AND J. DENT2 Departments of 1Medicine, 2Gastrointestinal Medicine, and 5Radiology, Royal Adelaide Hospital, and 7Department of Gastroenterology, Women’s and Children’s ...

Simmons, James G., Jolanta B. Pucilowska, and P. Kay Lund. Autocrine and paracrine actions of intestinal fibroblast-derived insulin-like growth factors. Am. J. Physiol. 276 (Gastrointest. Liver Physiol. 39): G817–G827, 1999.— Paracrine and autocrine actions of the insulin-like growth factors (IGFs) are inferred by local expression within the bowel. CCD-18Co cells, IEC-6 cells, and immunoneutral...

Ma, Thomas Y., Don Nguyen, Vuong Bui, Hanh Nguyen, and Neil Hoa. Ethanol modulation of intestinal epithelial tight junction barrier. Am. J. Physiol. 276 (Gastrointest. Liver Physiol. 39): G965–G974, 1999.—Previous studies have shown that high concentrations of ethanol ($40%) cause functional damage of the gastrointestinal epithelial barrier by direct cytotoxic effect on the epithelial cells. Th...

The present study was performed to evaluate the in vitro inhibitory potential of sarpogrelate and its active metabolite, M-1, on the activities of nine human cytochrome (CYP) isoforms. Using a cocktail assay, the effects of sarpogrelate on nine CYP isoforms and M-1 were measured by specific marker reactions in human liver microsomes. Sarpogrelate potently and selectively inhibited CYP2D6mediate...

Hellerstein, Marc K., and Richard A. Neese. Mass isotopomer distribution analysis at eight years: theoretical, analytic, and experimental considerations. Am. J. Physiol. 276 (Endocrinol. Metab. 39): E1146–E1170, 1999.—Mass isotopomer distribution analysis (MIDA) is a technique for measuring the synthesis of biological polymers. First developed approximately eight years ago, MIDA has been used f...

We discuss the properties of cosmic ray nuclearites, from the point of view of their search with large nuclear track detector arrays exposed at different altitudes, in particular with the SLIM experiment at the Chacaltaya high altitude lab (5290 m a.s.l.). We present calculations concerning their propagation in the Earth atmosphere and discuss their possible detection with CR39 and Makrofol nuc...

The nematode Caenorhabditis elegans was exposed to natural space radiation using the ESA Biorack facility aboard Spacelab on International Microgravity Laboratory 1, STS-42. For the major experimental objective dormant animals were suspended in buffer or on agar or immobilized next to CR-39 plastic nuclear track detectors to correlate fluence of HZE particles with genetic events. This configu...