Full-length IL-33 is a member of the IL-1 family of cytokines, which can act in an autocrine or paracrine manner by binding to the IL-33R on several different target cell types. In addition, IL-33 can act in an intracrine fashion by translocating to the nucleus, where it binds to the chromatin and modulates gene expression. In this article, we report that full-length IL-33, but not mature IL-33...

Sorting permutations by transpositions is an important and difficult problem in genome rearrangements. The transposition diameter TD(n) is the maximum transposition distance among all pairs of permutations in Sn. It was previously conjectured [H. Eriksson et al., Discrete Math., 241 (2001), pp. 289–300] that TD(n) ≤ n+1 2 . This conjecture was disproved by Elias and Hartman [IEEE/ACM Trans. Com...

BACKGROUND Although the majority of melanomas demonstrate high rates of mutations in B-RAF or N-RAS that result in constitutive activation of the mitogen-activated protein kinase-signaling pathway, emerging data suggest molecular differences among melanoma subtypes. In this study, the authors evaluated the contribution of B-RAF and N-RAS mutations to the pathogenesis of Spitzoid melanomas. ME...

BACKGROUND Innate T helper type 2 (Th2) immune responses mediated by interleukin (IL)-33, thymic stromal lymphopoietin (TSLP), and IL-25 have been shown to play an important role in pulmonary fibrosis of animal models; however, their clinical implications remain poorly understood. METHODS TSLP, IL-25, and IL-33 concentrations were measured in bronchoalveolar lavage fluids obtained from normal...

IntroductionSurgical trainees play an integral role in the perioperative workup and safety of patients undergoing surgery. This study was aimed to assess surgical trainees’ knowledge, attitudes practices on patient safety. MethodsA descriptive cross-sectional among 105 (males 96%, mean age 33 years, range 30-40 years) performed using self-administered validated questionnaires (Safety Attitude Q...

Polyunsaturated aldehydes (PUAs) are organic compounds mainly produced by diatoms, after cell wounding. These compounds are increasingly reported as teratogenic for species of grazers and deleterious for phytoplanktonic species, but there is still scarce information regarding concentration ranges and the composition of PUAs in the open ocean. In this study, we analyzed the spatial distribution ...

Using data of three well-observed type-II plateau supernovae (SNe II-P), SNe 1987A, 1999em and 2003hn; and two atmosphere models by Eastman et al. (1996) and Dessart & Hillier (2005b) we derive calibrations for bolometric corrections and effective temperature from BVI photometry. The typical scatter of the bolometric correction is 0.11 mag. With these results we obtain bolometric light curves a...