نتایج جستجو برای: myocardial metabolic uptake

تعداد نتایج: 490598  

Journal: :iranian journal of nuclear medicine 2001
mehdi payghambari seyed hassan firouzabadi mina taghizadeh

this study was performed to evaluate the tc-pyp spect role in determination of ami severity and extension. pyp spect imaging was done for 54 patients with ami, who met the who criteria. spect findings were correlated with lvef measurements. the abnormal scan was graded according to the intensity and was compared with the activity of the sternum in the same image. in addition, a segmental myocar...

2014
David J. C. Alders A. B. Johan Groeneveld Thomas W Binsl Johannes H. G. M. van Beek

At rest, myocardial perfusion is reasonably well matched to regional metabolic demand, although both are heterogeneously distributed. Nonuniform regional metabolic vulnerability during coronary stenosis would help to explain nonuniform necrosis during myocardial infarction. We investigated two questions: (1) does the metabolism-perfusion correlation diminish during coronary stenosis? (2) is hig...

Journal: :Clinical and experimental pharmacology & physiology 2013
Kimberley M Mellor James R Bell Rebecca H Ritchie Lea M D Delbridge

Clinical studies in humans strongly support a link between insulin resistance and non-ischaemic heart failure. The occurrence of a specific insulin-resistant cardiomyopathy, independent of vascular abnormalities, is now recognized. The progression of cardiac pathology linked with insulin resistance is poorly understood. Cardiac insulin resistance is characterized by reduced availability of sarc...

Journal: :Stem cells 2009
Massimiliano Gnecchi Huamei He Luis G Melo Nicolas Noiseaux Fulvio Morello Rudolf A de Boer Lunan Zhang Richard E Pratt Victor J Dzau Joanne S Ingwall

Administration of mesenchymal stem cells (MSCs) is an effective therapy to repair cardiac damage after myocardial infarction (MI) in experimental models. However, the mechanisms of action still need to be elucidated. Our group has recently suggested that MSCs mediate their therapeutic effects primarily via paracrine cytoprotective action. Furthermore, we have shown that MSCs overexpressing Akt1...

Journal: :Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1977
D A Epstein

In a patient with no recent myocardial insult, uptake of technetium-99m diphosphonate was noted in a region corresponding to massive calcification of the mitral annulus. The similarity of this finding to pathologic myocardial uptake is a potential source of error in the interpretation of myocardial scintigrams.

Journal: :American journal of physiology. Endocrinology and metabolism 2012
Curtis C Hughey Virginia L Johnsen Lianli Ma Freyja D James Pampee P Young David H Wasserman Jeffrey N Rottman Dustin S Hittel Jane Shearer

Intense interest has been focused on cell-based therapy for the infarcted heart given that stem cells have exhibited the ability to reduce infarct size and mitigate cardiac dysfunction. Despite this, it is unknown whether mesenchymal stem cell (MSC) therapy can prevent metabolic remodeling following a myocardial infarction (MI). This study examines the ability of MSCs to rescue the infarcted he...

2018
Bainian Chen Yifan Huang Dong Zheng Rui Ni Mark A. Bernards

Oversupply of bulk saturated fatty acids (SFA) induces metabolic disorders and myocardial dysfunction. We investigated whether, without causing metabolic disorders, the uptake of individual dietary SFA species alters lipid profiles and induces myocardial dysfunction. C57BL/6 mice were fed various customized long-chain SFA diets (40% caloric intake from SFA), including a beef tallow (HBD), cocoa...

2000
Thomas H. Hintze Hideo Tada Carl I. Thompson Fabio A. Recchia Kit E. Loke Manuel Ochoa Carolyne J. Smith Edward G. Shesely Gabor Kaley

Although the role of nitric oxide (NO) in the modulation of vascular tone has been studied and well understood, its potential role in the control of myocardial metabolism is only recently evident. Several lines of evidence indicate that NO regulates myocardial glucose metabolism; however, the details and mechanisms responsible are still unknown. The aim of this study was to further define the r...

Journal: :Circulation research 2000
H Tada C I Thompson F A Recchia K E Loke M Ochoa C J Smith E G Shesely G Kaley T H Hintze

Although the role of nitric oxide (NO) in the modulation of vascular tone has been studied and well understood, its potential role in the control of myocardial metabolism is only recently evident. Several lines of evidence indicate that NO regulates myocardial glucose metabolism; however, the details and mechanisms responsible are still unknown. The aim of this study was to further define the r...

Journal: :Circulation 1998
R R Russell R Yin M J Caplan X Hu J Ren G I Shulman A J Sinusas L H Young

BACKGROUND Myocardial ischemia increases glucose uptake through the translocation of GLUT1 and GLUT4 from an intracellular compartment to the sarcolemma. The present study was performed to determine whether hyperinsulinemia causes translocation of myocardial GLUT1 as well as GLUT4 in vivo and whether there are additive effects of insulin and ischemia on GLUT1 and GLUT4 translocation. METHODS AD...

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