The present study was aimed to investigate the probable role of Tyrphostin AG 490, a selective inhibitor of Janus kinase-2 (JAK-2) in hyperhomocysteinemia-induced attenuation of the cardioprotective potential of ischemic postconditioning (IPOC). Rats were administered L-methionine (1.7 g/kg/day, p.o.) for 4 weeks to produce hyperhomocysteinemia. Isolated Langendorff's perfused normal and hyperh...

OBJECTIVE To investigate the presence of myocardial injury in dogs hospitalized for snake envenomation and to examine its relationship with systemic inflammation. DESIGN Prospective case-control study. SETTING University teaching hospital and small animal referral hospital. ANIMALS Dogs naturally envenomed by the European viper (Vipera berus; n = 24), African puff adder (Bitis arietans; n...

Thrombolytic treatment in acute myocardial infarction achieves coronary patency in most patients.' Mortality in groups treated early after the onset of symptoms is significantly reduced,' but left ventricular function does not always improve.5 Myocardial necrosis during the period of vessel occlusion is partly responsible for the irreversible ventricular impairment that occurs even when the ves...

Diabetes is an independent risk factor for myocardial ischemia, and many epidemiological data and laboratory studies have revealed that diabetes significantly exacerbated myocardial ischemia/reperfusion injury and ameliorated protective effects. The present study aimed to determine whether pharmacological postconditioning with atorvastatin calcium lessened diabetic myocardial ischemia/reperfusi...