Streptomycin, the antibiotic produced by Streptomyces griseus, contains as a part of its structure a diguanidine derivative of scyllo-inositol called streptidine. Two major precursors of the streptidine portion of the molecule have now been defined, n-arginine and n-glucose (1, 2). Arginine plays a role in the formation of the guanidine side chains, whereas glucose is involved in the synthesis ...

PURPOSE To identify Myo/Nog cells in the adult retina and test their role in protecting retinal photoreceptors from light damage. METHODS Light damage was induced by exposing albino rats raised in dim cyclic light to 1000 lux light for 24 hours. In one group of rats, Myo/Nog cells were purified from rat brain tissue by magnetic cell sorting following binding of the G8 monoclonal antibody (mAb...

OBJECTIVES We used myocardial fractional flow reserve (FFR(myo)) and coronary flow reserve (CFR) to estimate cut-off values for assessment of the functional severity of coronary stenosis and myocardial ischemia, and we tested the usefulness of coronary blood hemodynamic measurements before and after plain old balloon angioplasty (POBA) and coronary artery bypass graft surgery (CABG). BACKGROU...

OBJECTIVE The most widely accepted hypothesis regarding the mechanism underlying lithium's therapeutic efficacy in manic-depressive illness (bipolar affective disorder) is the inositol depletion hypothesis, which posits that lithium produces a lowering of myo-inositol in critical areas of the brain and the effect is therapeutic. Lithium's effects on in vivo brain myo-inositol levels were invest...

Streptomycin, the antibiotic produced by Streptomyces griseus, contains as a part of its structure a diguanidine derivative of scyllo-inositol called streptidine. Two major precursors of the streptidine portion of the molecule have now been defined, n-arginine and n-glucose (1, 2). Arginine plays a role in the formation of the guanidine side chains, whereas glucose is involved in the synthesis ...

We recently identified the atypical myosin, Myosin VI, as a component of epithelial cell-cell junctions that interacts with E-cadherin. Recombinant proteins bearing the cargo-binding domain of Myosin VI (Myo VI-CBD) or the cytoplasmic tail of E-cadherin can interact directly with one another. In this report we further investigate the molecular requirements of the interaction between Myo VI-CBD ...

Developing human muscle contains inter-myofibre progenitors expressing Bmp-receptor 1a (Bmpr1a) and Myf5 that respond to stimulation with Bmp4. Here we ablate Bmpr1a in Myf5- and MyoD-expressing cells in vivo. Mutant mice reveal increased intramuscular fat and reduced myofibre size in selected muscles, or following muscle injury. Myo-endothelial progenitors are the most affected cell type: clon...

The functional effectiveness of a myo-electric prosthesis with sensory feedback compared with that of a split-hook is described. Thirty independent observations were made on a single subject with a right below-elbow amputation wearing the myo-electric prosthesis and the split-hook prosthesis. Using a first order autoregressive model for making inferences about the two sets of data, the split-ho...

The de novo synthesis of myo-inositol occurs via a two-step process: first, glucose 6-phosphate is converted into inositol 1-phosphate by an INO1 (myo-inositol-1-phosphate synthase; EC 5.5.1.4); then, it is dephosphorylated by an inositol monophosphatase. The myo-inositol can then be incorporated into PI (phosphatidylinositol), which is utilized in a variety of cellular functions, including the...

Soybean seeds accumulate soluble carbohydrates throughout development and maturation. Soluble carbohydrates may have important roles in seed germination, seed desiccation tolerance, and cold stress tolerance. The analysis of soluble carbohydrates in soybean seeds and other plant parts at various growth stages (Obendorf et al., 1998b & 2009; Kosina et al., 2009), under environmental stresses (Bl...