The BCR-ABL1-negative classic myeloproliferative neoplasms, polycythemia vera (PV), essential thrombocytemia (ET) and primary myelofibrosis are clonal stem cell disorders associated with an increased production of mature blood cells belonging preferentially to one cell linage. They share substantial phenotypic mimicry, can undergo phenotypic shifts (from PV to ET and vice versa) as well as evol...

1. Vardiman JW, Thiele J, Arber DA, et al. The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes. Blood. 2009;114(5):937-951. 2. Reilly JT. Pathogenetic insight and prognostic information from standard and molecular cytogenetic studies in the BCR-ABL-negative myeloproliferative neoplasms (MPNs). Leukemia....

Summary Myeloproliferative neoplasms (MPN) are clonal hematological conditions characterized by excessive production of one or more cell lines in the bone marrow. The blood cells produced often hyperactive their functions, which could lead to complications disorder‘s clinical course. We aimed define role granulocytic CD11b/CD18 expression for thrombotic risk MPN patients. investigated 110 patie...

Myeloproliferative neoplasms and myelodysplastic/myeloproliferative neoplasms are heterogeneous disorders. JAK2 mutation testing and karyotyping are routinely used for diagnosis but have not been incorporated into risk stratification in Philadelphia chromosome-negative myeloproliferative neoplasms. This study correlated cytogenetic abnormalities with disease stage and JAK2 status. A total of 17...

According toPubMed, the adjective“myeloproliferative”wasused for the first time in the title of a scientific paper by William Dameshek in 1951, when he published an editorial in Blood entitled, “Some speculations on the myeloproliferative syndromes.” In this article, featured in the recent Blood Flashback series, Dameshek introduced the concept of myeloproliferative disorders as conditions char...

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Introduction. Myelodysplastic/myeloproliferative neoplasms represent a group of rare hematologic malignancies with concomitant characteristics two different disorders. There are cytopenias and cytoses dysplastic morphology in the circulating blood hyperplastic bone marrow, respectively. Many cytogenetic molecular features have been found this entity, but t(2;11)(p21;q23)del(5) (q22;q33) has not...