نتایج جستجو برای: myeloid leukemia
تعداد نتایج: 302085 فیلتر نتایج به سال:
Background: It is well-established that myeloproliferative diseases coexist with CLAR and JAK2. In Ph+ chronic myeloid leukemia (CML), only a few case reports indicate the existence of CLAR, JAK2V617F, JAK2 exon 12 mutations. Methods: This study examined CALR mutation profiles in Sudanese Chronic Myeloid Leukemia patients Philadelphia-positive patients. Blood samples were collected from 100 CML...
OBJECTIVE The aim of this study was to determine the efficiency of the high throughput FISH analysis (HTFA) method for detecting genetic alterations in hematological malignancies, which is a new bacterial artificial chromosome array-based approach. MATERIALS AND METHODS We performed a HTFA study of bone marrow aspiration and peripheral blood samples of 77 cases (n=19 myelodysplastic syndrome,...
Acute myeloid leukemia originates from leukemia-initiating cells that reside in the protective bone marrow niche. CXCR4/CXCL12 interaction is crucially involved in recruitment and retention of leukemia-initiating cells within this niche. Various drugs targeting this pathway have entered clinical trials. To evaluate CXCR4 imaging in acute myeloid leukemia, we first tested CXCR4 expression in pat...
Acute myeloid leukemia (AML) is a disease characterized by neoplastic transformation and abnormality of progenitor cells differentiation from cells. In AML there heterogeneous in hematopoietic cells, this has been identified affects the balance between proliferation, survival body Mutation FMS-like tyrosin kinase 3 (FLT3) gene causes overexpression which one most often found mechanism that coul...
Acute Myeloid Leukemia 753-762 Arsenic trioxide induces accumulation of cytotoxic levels of ceramide in acute promyelocytic leukemia and adult T-cell leukemia/lymphoma cells through de novo ceramide synthesis and inhibition of glucosylceramide synthase activity Ghassan S. Dbaibo, Youmna Kfoury, Nadine Darwiche, Shoghag Panjarian, Lina Kozhaya, Rihab Nasr, Mazen Abdallah, Olivier Hermine, Marwan...
A case is described of acute leukemia whose neoplastic cells possessed myeloid and lymphoid characteristics. Neoplastic cells possessed cytoplasmic granules containing Sudan black B material and diaminobenzidine myeloperoxidase. In addition, these luekemic cells were positive for terminal deoxynucleotidyl transferase. Ia antigen, and the common acute lymphocytic leukemia antigen. These findings...
Пре- и посттрансплантационные факторы, ассоциированные с первичной недостаточностью тяжелой дисфункцией трансплантата после аллогенной трансплантации гемопоэтических стволовых клеток при хроническом миелоидном лейкозеPre- and post-transplantation factors associated with primary graft failure severe poor function after allogeneic hematopoietic stem cell transplantation for chronic myeloid leukemia
Background and Objective: Acute myeloid leukemia (AML) is a clonal proliferation of immature myeloid progenitors in the bone marrow. Multiple genetic and environmental factors have been reported to be involved in the pathogenesis of AML. Cytochromes, such as cytochrome P450 are among detoxifying enzymes whose aberrant expression can make individuals susceptible to a variety of cancers and leuke...
some of the genotypes of cytokines are associated with acute graft versus host disease after bone marrow transplantation. the purpose of the present investigation was to find out the possible association between transforming growth factor beta-1 (tgf-β1) codon 25 polymorphism (rs:1800471) and acute graft versus host disease (agvhd) after bone marrow transplantation from the sibling with the sim...
BACKGROUND Until recently, few molecular aberrations were recognized in acute lymphoblastic leukemia of T-cell origin; novel lesions have recently been identified and a certain degree of overlap between acute myeloid leukemia and T-cell acute lymphoblastic leukemia has been suggested. To identify novel T-cell acute lymphoblastic leukemia entities, gene expression profiling was performed and cli...
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