نتایج جستجو برای: mycn

تعداد نتایج: 1228  

2014
Yuji Tanno Yoshinori Watanabe

Neuroblastoma is a disease in which malignant cells form in nerve tissue. Amplification of MYCN, a member of the MYC proto-oncogene family, is frequently observed in neuroblastoma, and it is associated with malignant phenotype and poor prognosis.1 in the April 1, 2014 issue of Cell Cycle, Murakami-Tonami et al.2 reported that downregulation of sMC2, a subunit of condensin, leads to cell death t...

Journal: :Clinical and translational discovery 2023

Abstract Neuroblastoma (NB) is an embryonal deadly cancer in childhood driven by MYC or MYCN‐driven oncogenic signaling. The amplification of MYCN leads to malignant progression NB and poor prognosis. Traditional chemotherapy still a standard treatment for NB. Most the cytostatic drugs take function anti‐neuroblastoma. However, children with exhibit different clinical outcome variability biolog...

Journal: :Cancer research 2009
Robert J Rounbehler Weimin Li Mark A Hall Chunying Yang Mohammad Fallahi John L Cleveland

Neuroblastoma is a pediatric malignancy that arises from the neural crest, and patients with high-risk neuroblastoma, which typically harbor amplifications of MYCN, have an extremely poor prognosis. The tyrosine hydroxylase (TH) promoter-driven TH-MYCN transgenic mouse model faithfully recapitulates many hallmarks of human MYCN-amplified neuroblastoma. A key downstream target of Myc oncoprotein...

2009
Y. Jamin E. R. Cullis L. Vaughan D-M. Koh L. Chesler S. P. Robinson

Introduction Neuroblastoma is the most common extracranial childhood solid tumour, accounting for between 7-10% of paediatric cancers, and originates in peripheral nerve tissues (1). The proto-oncogene MYCN is amplified in 25% of high-risk neuroblastoma and is associated with an aggressive tumour phenotype, enhanced tumour angiogenesis and poor clinical prognosis (2). The Mycn oncoprotein is hi...

2017
Ivan Petrov Maria Suntsova Elena Ilnitskaya Sergey Roumiantsev Maxim Sorokin Andrew Garazha Pavel Spirin Timofey Lebedev Nurshat Gaifullin Sergey Larin Olga Kovalchuk Dmitry Konovalov Vladimir Prassolov Alexander Roumiantsev Anton Buzdin

Neuroblastoma is a pediatric cancer arising from sympathetic nervous system. Remarkable heterogeneity in outcomes is one of its widely known features. One of the traits strongly associated with the unfavorable subtype is the amplification of oncogene MYCN. Here, we performed cross-platform biomarker detection by comparing gene expression and pathway activation patterns from the two literature r...

2014
Raul Calero Esther Morchon John Inge Johnsen Rosario Serrano

Neuroblastoma, a tumor of the peripheral sympathetic nervous system, is the most common and deadly extracranial tumor of childhood. The majority of high-risk neuroblastoma exhibit amplification of the MYCN proto-oncogene and increased neoangiogenesis. Both MYCN protein stabilization and angiogenesis are regulated by signaling through receptor tyrosine kinases (RTKs). Therefore, inhibitors of RT...

2014
Viktoryia Sidarovich Valentina Adami Alessandro Quattrone

Neuroblastoma is the most common extracranial solid tumor of infancy. Amplification of MYCN oncogene is found in approximately 20 % of all neuroblastoma patients and correlates with advanced disease stages, rapid tumor progression, and poor prognosis, making this gene an obvious therapeutic target. However, being a transcriptional factor MYCN is difficult for pharmacological targeting, and ther...

Journal: :Cancer research 2008
Michael D Hogarty Murray D Norris Kimberly Davis Xueyuan Liu Nicholas F Evageliou Candace S Hayes Bruce Pawel Rong Guo Huaqing Zhao Eric Sekyere Joanna Keating Wayne Thomas Ngan Ching Cheng Jayne Murray Janice Smith Rosemary Sutton Nicola Venn Wendy B London Allen Buxton Susan K Gilmour Glenn M Marshall Michelle Haber

Neuroblastoma is a frequently lethal childhood tumor in which MYC gene deregulation, commonly as MYCN amplification, portends poor outcome. Identifying the requisite biopathways downstream of MYC may provide therapeutic opportunities. We used transcriptome analyses to show that MYCN-amplified neuroblastomas have coordinately deregulated myriad polyamine enzymes (including ODC1, SRM, SMS, AMD1, ...

Journal: :Molecular cancer therapeutics 2007
Cihan Cetinkaya Anne Hultquist Yingtao Su Siqin Wu Fuad Bahram Sven Påhlman Irina Guzhova Lars-Gunnar Larsson

The MYCN protooncogene is involved in the control of cell proliferation, differentiation, and survival of neuroblasts. Deregulation of MYCN by gene amplification contributes to neuroblastoma development and is strongly correlated to advanced disease and poor outcome, emphasizing the urge for new therapeutic strategies targeting MYCN function. The transcription factor N-Myc, encoded by MYCN, reg...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2012
Hideki Izumi Yasuhiko Kaneko

Asymmetric cell division (ACD) is believed to be a physiological event that occurs during development and tissue homeostasis in a large variety of organisms. ACD produces two unequal daughter cells, one of which resembles a multipotent stem and/or progenitor cell, whereas the other has potential for differentiation. Although recent studies have shown that the balance between self-renewal and di...

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