Common metabolic and endocrine alterations exist across a wide range of muscular dystrophies. Skeletal muscle plays an important role in glucose metabolism and is a major participant in different signaling pathways. Therefore, its damage may lead to different metabolic disruptions. Two of the most important metabolic alterations in muscular dystrophies may be insulin resistance and obesity. How...

Hypoglycemia in non-diabetic patients with heart failure is a rare finding. It is thought to be caused by hepatic dysfunction secondary to chronic passive congestion, and reduced gluconeogenesis. In this report we present a 23-year-old man with a history of Duchenne muscular dystrophy hospitalized for decompensated heart failure and implantable cardioverter defibrillator shock. Laboratory exami...

• duchenne muscular dystrophy o onset 3 to 5 yrs o clinical § weakness o distribution § proximal > distal § symmetric § legs & arms § most involved muscles: adductor magnus in legs § relatively spared muscles: gracilis & sartorius o course § reduced motor function by 2 to 3 years § steady decline in strength: after 6 to 11 years o gowers sign: standing up with the aid of hands pushing on knees ...

to the editor; tramadol, a synthetic opioid is mainly used to treat acute and chronic pain. although this drug is not an over-the-counter medication, it has been illicitly accessible to and abused by opium addicts (1-3). studies showed excessive and widespread use of tramadol in iran (1-4). tramadol may cause constipation, drowsiness, tachycardia and respiratory distress, while the most severe ...

abstract objective autosomal recessive spinal muscular atrophy (sma) is, after cystic fibrosis, the second most common fatal monogenic disorder and the second most common hereditary neuromuscular disease after duchenne dystrophy. the disease is characterized by degeneration of anterior horn cells leading to progressive paralysis with muscular atrophy. depending on the clinical type (werdnig- ho...

duchenne muscular dystrophy (dmd) and the milder allelic becker muscular dystrophy (bmd) are x-linked disorders. both dmd & bmd result from heterogenous mutation in the dystrophin gene and in about 65% of the cases one or more exons of the gene are deleted or duplicated. one third of cases arise from new mutation and the rest are familial. to analyze the prevalence of deletion in iranian patien...

Background: Limb-girdle muscular dystrophy 2E (LGMD 2E), recently renamed as autosomal recessive limb-girdle dystrophy-4 (LGMDR4), is characterized by the lack of beta-sarcoglycan, normally expressed in skeletal muscles and cardiomyocytes. We hypothesized that progressive respiratory left ventricular (LV) failure LGMDR4 could be associated with age interrelated phenomena disease's natural histo...