The calcifying odontogenic cyst represents a heterogeneous group of lesions that exhibits a variety of clinicopathologic and behavioral features. Therefore, a proper categorization of the cases is needed for better understanding of each variant. Ameloblastoma is one of the well-known odontogenic tumors that could be associated with calcifying odontogenic cyst. Very few cases of ameloblastomatou...

Abstract Background A 15-year-old male attended the paediatric dental department as an urgent self-referral. Clinical examination revealed a large, firm lesion in right maxilla which had been slowly increasing size for past year. No altered sensation and facial numbness was detected. The upper central incisor (UR1) missing however, primary extracted at dentist three months prior. Investigations...

Neurturin (NTN) is a recently characterized member of the glial cell line-derived neurotrophic factor (GDNF)-family which, like GDNF, can promote the survival of certain populations of neuronal cells in peripheral and central nervous systems. To elucidate the roles of NTN and a novel glycosyl-phosphatidylinositol (GPI)-linked receptor protein GFRalpha-3, a member of GDNF-family receptor alpha, ...

objective: pulp and periodontal tissues are well-known sources of mesenchymal stem cells (mscs) that provide a promising place in tissue engineering and regenerative medicine. the molecular mechanisms underlying commitment and differentiation of dental stem cells that originate from different dental tissues are not fully understood. in this study, we have compared the expression levels of pluri...

Colorectal adenomas and possibly some hyperplastic polyps are precursors of colorectal cancer. Tobacco use is associated in epidemiologic studies with these polyps, although links between smoking and colorectal cancer are less consistent. To characterize the role of tobacco in early colorectal carcinogenesis, we compared tobacco use among 4,383 subjects with histologically verified benign (hype...

BACKGROUND: Pulp damage can lead to dentinogenesis impairment, irreversible pulpitis, or pulp necrosis. Despite being the most used endodontic procedure treat damaged pulp, root canal therapy only results in nonvital teeth which are prone fractures and secondary infection. Pulp-dentin regeneration has a potential regenerate structure similar normal pulp-dentin complex, be achieved by combining ...