pRLla (IPGLPLSL) is the Ld-binding tumor rejection antigen peptide recognized by ("l'I.s on »VI,ISA-radiation leukemia KI I. We demon strated that in vivo and in vitro sensitization with pRLla multiple antigen peptide (MAP), but not with the pRLla peptide itself, generated pRLlaspecific CTLs in the spleen cells of BALB/c mice. No enhancement of cytotoxicity was observed by emulsifying pRLla MA...

Complement is one of the major effector pathways by which antibodies destroy cellular targets to which they bind. C3 plays a pivotal role in this process both by serving as a direct opsonin after attaching to surfaces in the form of C3b and also by leading to downstream assembly of the membrane attack complex. In addition to fixation of C3, antibodies can opsonize cellular targets through ligat...

Sexually mature female tilapia were exposed to sublethal concentrations of waterborne Cu and/or Cd over 6 days, and subsequent body concentrations of these metals were determined in several organs. The results show that the distribution of Cu and Cd was metal and organ specific. This is demonstrated, for example, by the observation that in tilapia, Cu exposure did not result in Cu accumulation ...

The aim of the study was to establish to what degree the 24-week exposure of a rat to 5 and 50 mg Cd/dm3 affects the proliferating activity of cells with PCNA and Ki-67 nuclear immunoreactivity in the submandibular gland cells. The control animals received only redistilled water to drink. The group I rats were given 5 mg Cd/dm3, while the group II animals were given 50 mg Cd/dm3. The highest co...

Running title: Antigen-expression and specific T-cell responses in Myeloma th framework program OVER-MyR. Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Despite a variety of therapeutical approaches including high dose chemotherapy with subsequent autologous stem cell transplantation, Multiple Myeloma remains an almost incurable disease. Ne...

Monosymptomatic unilateral optic neuritis is a common first manifestation of multiple sclerosis. Abnormal T cell responses to myelin components including myelin basic protein (MBP), proteolipid protein (PLP), and myelin-associated glycoprotein (MAG) have been implicated in the pathogenesis of multiple sclerosis. Antigen-reactive T helper type 1 (Th1)-like cells that responded by interferon gamm...

background: anaphylactic reactions, such as urticaria, edema, respiratory symptoms, and anaphylactic shock often complicate the course of cystic echinococcosis (ce). methods: to investigate the role of the ige immunoreactive antigen 5 (ag 5) in the sero-positive patients with ce, we determined n-terminal of 57 kda subunit of ag5 responsible for ige and c-terminal of this active antigen related ...

Multiple sclerosis, an immune-mediated disease of the central nervous system, is characterized by the impaired function of regulatory cells that fail to suppress self-reactive effector cells. We have previously found that polysaccharide A, a capsular antigen derived from the human gut commensal Bacteroides fragilis, can induce a population of regulatory T cells. Herein, we demonstrate that naïv...

Adoptive transfer of chimeric antigen receptor-transduced T cells is a promising strategy for cancer immunotherapy. The CD38 molecule, with its high expression on multiple myeloma cells, appears a suitable target for antibody therapy. Prompted by this, we used three different CD38 antibody sequences to generate second-generation retroviral CD38-chimeric antigen receptor constructs with which we...