OBJECTIVES/HYPOTHESIS The purpose of this study was to investigate the feasibility of performing mucosal elevation of a vocal fold microflap in a rabbit model and to measure the acute healing of rabbit microflap incisions compared to control vocal folds. STUDY DESIGN Prospective animal study. METHODS Ten New Zealand white rabbits were used in this study. All rabbits received a 3-mm incision...

Absorption of glucose from the lumen of the intestine into enterocytes is accomplished by sodium-glucose co-transporter 1 (SGLT1). In the majority of mammalian species, expression (this includes activity) of SGLT1 is upregulated in response to increased dietary monosaccharides. This regulatory pathway is initiated by sensing of luminal sugar by the gut-expressed sweet taste receptor. The object...

Abstract Background TL1A is a TNF super family member cytokine encoded by TNFSF15 and reported to be disease susceptibility gene for IBD. The relationship between expression IBD pathophysiology, clinical course, endoscopic findings was not sufficiently clear. aim of this study clarify the correlation in intestinal mucosa UC severity, course. Methods subjects were patients with who visiting our ...

pneumatosis cystoides intestinalis (pci) is a rare condition charachterized by the presence of multiple gases filled cysts in the gastro intestinal tract. in this article we present three cases with different features, who at the end evaluation pci was diagnosed. the first patient present with rectorrhagia (submucosal pci). the second patient present with dyspepsia (subserosal intestinal pci) a...

Intranasal (i.n.) vaccination with two suboptimal doses of 8 microg of deglycosylated chain A ricin (DGCA) stimulated low anti-ricin ELISA IgG and neutralizing antibody responses and the vaccine was only marginally protective against a lethal ricin toxin aerosol challenge. However, in the presence of 4, 2, or 1 microg of the mucosal adjuvant LTR72, a mutant of the heat-labile enterotoxin of Esc...

Administration of pharmacological doses of epidermal growth factor (EGF) or transforming growth factor-alpha (TGF-alpha) in young rats stimulates gastric mucosal proliferation, but, in aged rats, the same treatment inhibits proliferation. This may be due to enhanced ligand-induced internalization of EGF receptor (EGFR). In support of this, we demonstrated that although a single injection of EGF...

Our previous studies had suggested a link between bile salt stimulation of colonic epithelial proliferation and the release and oxygenation of arachidonate via the lipoxygenase pathway. In the present study, we examined the role of reactive oxygen versus end products of arachidonate metabolism via the cyclooxygenase and lipoxygenase pathways in bile salt stimulation of rat colonic epithelial pr...