نتایج جستجو برای: mucin

تعداد نتایج: 10038  

Journal: :American journal of physiology. Lung cellular and molecular physiology 2007
Lubna H Abdullah C William Davis

Mucus hyperproduction in pulmonary obstructive diseases results from increased goblet cell numbers and possibly increased cellular mucin synthesis, occurring in response to inflammatory mediators acting via receptor tyrosine kinases (RYK) and tyrosine phosphorylation (Y-Pi) signaling pathways. Yet, increased mucin synthesis does not lead necessarily to increased secretion, as mucins are stored ...

Journal: :Journal of clinical pathology 1987
C Rigaud W V Bogomoletz

Forty primary carcinomas of the thyroid of different histological types were reviewed and studied histochemically, with the aim of identifying and assessing "mucin secretion". The patterns of extracellular "pure alcianophilia" and "mixed alcianophilia" were noted in 7.5% and about 50% of these tumours, respectively. A critical review of the pitfalls in methods and interpretation of mucin histoc...

Journal: :The Laryngoscope 2013
Chiung-Ming Chen Ching-Wen Chiang

Allergic mucin is described as thick, peanut butter-like mucus impacted in the paranasal sinuses of patients with allergic fungal rhinosinusitis. The presence of allergic mucin in the middle ear has never been reported. We encountered a 65-year-old female with allergic mucin found impacted in her left middle ear and mastoid cavity during revised tympanoplasty surgery at our institute. Bilateral...

Journal: :Journal of clinical pathology 1985
C Rigaud F Peltier W V Bogomoletz

An unusual case of a mucin secreting benign microfollicular adenoma of the thyroid in a 30 year old euthyroid woman is reported. Histologically, the lesion was characterised by follicular cells with the appearance of signet ring cells. Histochemistry showed the mucin content of these cells to consist uniformly of sulphated acid mucins; positive thyroglobulin immunostaining was also shown. The p...

2001
Barry J. Campbell Gillian E. Rowe Keith Leiper Jonathan M. Rhodes

Mucins in ulcerative colitis and colon cancer share common properties of reduced sulfation and increased oncofetal carbohydrate antigen expression. It has previously been shown that there is no simple correlation between these changes and the activity of the relevant glycosyl-, sialyl-, and sulfo-transferases. We examined mucin sulfation and expression of oncofetal Thomsen-Friedenreich (TF) ant...

2016
KHAYAL AL-KHAYAL MAHA ABDULLA OMAR AL-OBAID AHMAD ZUBAIDI MANSOOR-ALI VAALI-MOHAMMED ABDULMALIK ALSHEIKH REHAN AHMAD

Mucin overexpression has been implicated in the tumorigenesis and progression of colorectal carcinoma (CRC). However, data obtained on the prognostic importance of mucin expression in CRC is inconsistent. Due to lack of data on mucin expression and the increase in CRC incidence in Saudi Arabia, the aim of the present study was to analyze the mucin expression profile in patients with CRC in this...

Journal: :The American journal of physiology 1999
D-H Hong G Petrovics W B Anderson J Forstner G Forstner

Treatment of HT-29 cells with phorbol 12-myristate 13-acetate (PMA), an activator of protein kinase C (PKC), induces MUC2 expression. To investigate the role of PKC in regulating mucin genes in intestinal cells, we examined the regulation of MUC1, MUC2, MUC5AC, MUC5B, and MUC6 expression in two human mucin-producing colonic cell lines, T84 and HT29/A1. T84 and HT29/A1 cells (at 80-90% confluenc...

Journal: :Investigative ophthalmology & visual science 2014
Hun Lee Eung Kweon Kim Ji Yeon Kim Yu-Mi Yang Dong Min Shin Kyung Koo Kang Tae-im Kim

PURPOSE We evaluated whether DA-6034 is involved in mucin secretion via P2Y receptor activation and/or intracellular Ca2+ concentration ([Ca2+]i) change. Also, we investigated the effect of P2Y receptor inhibitors or Ca2+ chelators on the DA-6034-induced mucin secretion and [Ca2+]i increases. METHODS Effects of DA-6034 on mucin expression in primary, cultured, conjunctival epithelial cells wa...

Journal: :World Journal of Surgical Oncology 2007
Yo-ichi Yamashita Kengo Fukuzawa Akinobu Taketomi Shinichi Aishima Tomoharu Yoshizumi Hideaki Uchiyama Eiji Tsujita Norifumi Harimoto Noboru Harada Kenzo Wakasugi Yoshihiko Maehara

BACKGROUND Although intraductal papillary mucinous neoplasm (IPMN) of the pancreas is acceptable as a distinct disease entity, the concept of mucin-secreting biliary tumors has not been fully established. CASE PRESENTATION We describe herein a case of mucin secreting biliary neoplasm. Imaging revealed a cystic lesion 2 cm in diameter at the left lateral segment of the liver. Duodenal endoscop...

Journal: :Anticancer research 2004
David C Dorn Ulf Harnack Gabriele Pecher

The nucleoside analogue gemcitabine displays therapeutic effects mainly against breast, ovarian and pancreatic cancer. Mucin, encoded by the gene MUC1, is a well-established tumor antigen expressed on these tumors. Knowledge of possible effects of chemotherapeutic drugs on the level of mucin epitope expression is important for the design of clinical protocols combining chemo- and immunotherapeu...

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