نتایج جستجو برای: mtnr 1a

تعداد نتایج: 31311  

Journal: :American journal of physiology. Cell physiology 2011
Pei-Chun Chen Cathrin E Bruederle Herbert Y Gaisano Show-Ling Shyng

The pancreatic ATP-sensitive potassium (K(ATP)) channel consisting of four inwardly rectifying potassium channel 6.2 (Kir6.2) and four sulfonylurea receptor SUR1 subunits plays a key role in insulin secretion by linking glucose metabolism to membrane excitability. Syntaxin 1A (Syn-1A) is a plasma membrane protein important for membrane fusion during exocytosis of insulin granules. Here, we show...

Journal: :Antimicrobial agents and chemotherapy 2010
Margaret Robinson Huiling Yang Siu-Chi Sun Betty Peng Yang Tian Nikos Pagratis Andrew E Greenstein William E Delaney

The hepatitis C virus (HCV) subgenomic replicon is the primary tool for evaluating the activity of anti-HCV compounds in drug discovery research. Despite the prevalence of HCV genotype 1a (approximately 70% of U.S. HCV patients), few genotype 1a reporter replicon cell lines have been described; this is presumably due to the low replication capacity of such constructs in available Huh-7 cells. I...

Journal: :Genes & development 2012
Joong Youn Cho Kayam Chak Benjamin J Andreone Joseph R Wooley Alex L Kolodkin

The Drosophila transmembrane semaphorin-1a (Sema-1a) is a repulsive guidance cue that uses the Plexin A (PlexA) receptor during neural development. Sema-1a is required in axons to facilitate motor axon defasciculation at guidance choice points. We found that mutations in the trol gene strongly suppress Sema-1a-mediated repulsive axon guidance. trol encodes the phylogenetically conserved secrete...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2010
Arturo Diaz Xiaofeng Wang Paul Ahlquist

Positive-strand RNA viruses replicate their genomes on membranes with virus-induced rearrangements such as single- or double-membrane vesicles, but the mechanisms of such rearrangements, including the role of host proteins, are poorly understood. Brome mosaic virus (BMV) RNA synthesis occurs in ≈70 nm, negatively curved endoplasmic reticulum (ER) membrane invaginations induced by multifunctiona...

Journal: :Journal of immunology 2006
Jennifer M Mataraza Joseph R Tumang Maria R Gumina Sean M Gurdak Thomas L Rothstein Thomas C Chiles

Peritoneal B-1a cells differ from splenic B-2 cells in the molecular mechanisms that control G(0)-S progression. In contrast to B-2 cells, cyclin D2 is up-regulated in a rapid and transient manner in phorbol ester (PMA)-stimulated B-1a cells, whereas cyclin D3 does not accumulate until late G(1) phase. This nonoverlapping expression of cyclins D2 and D3 suggests distinct functions for these pro...

Journal: :Canadian Journal of Chemistry 1994

Journal: :Open Access Journal of Endocrinology 2018

Journal: :Atlas of Genetics and Cytogenetics in Oncology and Haematology 2011

Journal: :Atlas of Genetics and Cytogenetics in Oncology and Haematology 2012

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