Abstract The development of nanoparticle agents for MRI-guided radiotherapy is growing at an increasing pace, with clinical trials now underway and many pre-clinical evaluation studies ongoing. Gadolinium iron-oxide-based nanoparticles remain the most clinically advanced to date, although several promising candidates are currently under varying stages development. Goals current future generatio...

The objective of this study was to assess the utility of CT-MRI image fusion software and compare both prostate volume and localization with CT and MRI studies. We evaluated the differences in clinical volumes in patients undergoing three-dimensional conformal radiation therapy for localized prostate cancer. After several tests performed to ensure the quality of image fusion software, eight pat...

We compared the prostate volumes and rectal doses calculated by CT and CT-MRI fusion, and verified the usefulness of CT-MRI fusion in three-dimensional (3D) radiotherapy planning for localized prostate cancer. Three observers contoured the prostate and rectum of 13 patients with CT and CT-MRI fusion. Prostate delineations were classified into three sub-parts, and the volumes and distances to th...

Abstract INTRODUCTION Patients with multiple sclerosis (MS) may be at higher risk of brain tumors (Khalil 2012, London 2020, etc.). However, MS patients have been reported to adverse effects from radiotherapy, a mainstay CNS treatment. In the last ten years, radiation techniques improved. We submit case report an patient demyelinating lesions shortly after therapy for astrocytoma and review lit...

methods study on 34 patients diagnosed with rectal adenocarcinoma referred to oncology clinic was conducted. the treatment plan included 4050 cgy radiotherapy and 5fu, xeloda chemotherapy. all patients were assessed with 1/5 t mri 6 to 8 weeks after treatment. t1 and t2 images with sagittal, cronal and axial planes with and without contrast agent were obtained and interpreted by two radiologist...

Colorectal cancer (CRC) is the leading cause of cancer-related death worldwide. Rectal constitutes around one-third all CRCs. The current standard care patients with locally advanced rectal neoadjuvant radio/chemo-radiotherapy; however, treatment differs substantially across countries. Novel markers are required to optimize treatment. Extramural vascular invasion (EMVI) a well-established magne...

Conformal radiotherapy is a therapeutic method requiring medical imaging, generally CT images to obtain Hounsfield number and electronic density data indications. The use of MRI simultaneously with CT imposes to deform CT images and superimpose them on MR images. The aim of this paper is to propose a nonridgid matching method between the two modalities (CT and MRI). The transformation model is ...

BACKGROUND Surgery plus adjuvant radiotherapy is standard care for locally advanced prostate cancer (stage pT3R1). Intraoperative low-energy photon radiotherapy offers several advantages over external beam radiotherapy, and several systems are now available for its delivery, using spherical applicators, which require only limited shielding. The aim of this study was to evaluate the feasibility ...

Liposomal drug delivery appears to improve the antitumor effect and reduce toxicity compared with the free drug. The therapeutic index may be improved further by combining cytotoxic drugs and radiotherapy. Successful therapy requires that the cytotoxic agents reach the tumor cells. Therefore, we studied tumor growth and the microdistribution of liposomal doxorubicin (Caelyx) with and without ad...