In this study, a 4D dosimetry concept was developed. This concept included a method for calculation of 3D reference absorbed dose matrices at every control point of the delivery using a clinical treatment planning system (TPS). Further, the gamma evaluation method was extended to incorporate the 4 dimension of the TPS calculated dose distributions. The applications of the 4D dosimetry concept o...

Fricke gel dosimetry is a valuable method for in-phantom dose measurements in complex irradiation modalities like IMRT and BNCT. Implementation of this dosimetry technique requires dedicated instruments capable of measuring and further analysis immediately in situ at the radiation facility. This work presents a novel and integral dosimetry system aimed to attain portability requirements. The me...

Radiation dosimetry is fundamental in Medical Physics, involving patients and phantom dosimetry. In both cases thennoluminescence dosimetry (TLD) is the most appropriate technique for measuring the absorbed dose. In this paper thennoluminescence phenomenon as well as the use of TLD in radiodiagnosis and radiotherapy for in vivo or in phantom measurements is discussed. Some results of measuremen...

UNLABELLED We developed a technique that allows the routine integration of PET in stereotactic neurosurgery, including radiosurgery. We report our clinical experience with the combined use of metabolic (i.e., PET) and anatomic (i.e., MRI and CT) images for the radiosurgical treatment of brain tumors. We propose a classification describing the relative role of the information provided by PET in ...

BACKGROUND Tumor antigen (TA)-targeted monoclonal antibody (mAb) immunotherapy can be effective for the treatment of a broad range of cancer etiologies; however, these approaches have demonstrated variable clinical efficacy for the treatment of patients with prostate cancer (PCa). An obstacle currently impeding translational progress has been the inability to quantify the mAb dose that reaches ...

An urgent requirement for 3D dosimetry has been recognized because of high failure rate (~25%) in RPC credentialing, which relies on point and 2D dose measurements. Comprehensive 3D dosimetry is likely to resolve more errors and improve IMRT quality assurance. This work presents an investigation of the feasibility of PRESAGE/optical-CT 3D dosimetry in the Radiologic Physics Center (RPC) IMRT H&...

Abstract Purpose/Objective(s) Re-irradiation (ReRT) is often used to treat recurrent high grade glioma (HGG). There limited literature regarding the patterns of recurrence following ReRT, which was investigated in current study. Materials/METHODS Patients with available radiation (RT) contours, dosimetry, and imaging-based evidence were included retrospective All patients treated fractionated R...

There is a long history of absorbed dose calculations being performed to evaluate the risks involved in the application of radiopharmaceuticals to medical studies. In the 1940s, Marinelli, Quimby, and Hine (1–3) published a set of articles that presented a summary and approach to radionuclide dosimetry. In 1956 Loevinger et al. (4) summarized the field at that point, and then in 1968 the newly ...