نتایج جستجو برای: monophosphoryl lipid a

تعداد نتایج: 13481193  

Journal: :Revista do Instituto de Medicina Tropical de Sao Paulo 2012
Joshua M Mutiso John C Macharia Evans Taracha Kellern Wafula Hitler Rikoi Michael M Gicheru

In this study, we report on the safety and skin delayed-type hypersensitivity (DTH), responses of the Leishmania donovani whole cell sonicate antigen delivered in conjunction with alum-BCG (AlBCG), Montanide ISA 720 (MISA) or Monophosphoryl lipid A (MPLA) in groups of vervet monkeys. Following three intradermal injections of the inoculums on days 0, 28 and 42, safety and DTH responses were asse...

2011
Nicola Scichilone Chiara Minaldi Roberta Santagata Salvatore Battaglia Gaetana Camarda Vincenzo Bellia

BACKGROUND The ultra-short course pre-seasonal allergy vaccine, containing appropriate allergoids with the adjuvant monophosphoryl lipid A (MPL), may be effective in treating allergic symptoms. OBJECTIVE To explore the timing of the immunological responses to the pre-seasonal allergy vaccine. METHODS Four subcutaneous injections of the active product (Pollinex Quattro) were administered to ...

2014
Stefan Schülke Lothar Vogel Adam Flaczyk Sonja Wolfheimer Stefan Vieths Stefan Scheurer

Monophosphoryl lipid A (MPL) is a non-toxic TLR4 ligand, derived from Salmonella minnesota R595 (Re) lipopolysaccharide (LPS) by chemical modification. It is clinically used as an adjuvant for cancer treatment (Fendrix, Ceravix) and allergen specific immunotherapy (Pollinex Quattro, ORALVAC). Nevertheless, reports on the mechanism of adjuvant activity are limited. The aim of this study was to c...

Journal: :The Journal of pharmacology and experimental therapeutics 1998
A Tosaki N Maulik G T Elliott I E Blasig R M Engelman D K Das

Preconditioning with monophosphoryl lipid A (MLA) protects rabbit hearts from prolonged ischemic reperfusion injury by a mechanism involving inducible nitric oxide synthase (iNOS) activation. This study was undertaken to determine whether MLA also could precondition rat hearts in a similar manner. Rats were injected with two different doses of MLA (300 microg/kg or 450 microg/kg i.v.) or vehicl...

2008
Abdo Konur Andreas Graser Inga Klamp Sebastian Kreiter Abderraouf Selmi Mustafa Diken Christoph Huber Özlem Türeci Ugur Sahin

As shown previously, encapsulation of a peptide derived from tyrosinase-related protein2 (TRP2) into liposomes (artificial virus envelope (AVE) 3) resulted in combination with CpG-oligodeoxynucleotides in the induction of higher numbers of antigen-specific T cells compared to vaccination with free TRP2. Here, we present further data with regard to optimal antigen dose, the relevance of vaccine ...

2018
Agnieszka Sulima Rashmi Jalah Joshua F G Antoline Oscar B Torres Gregory H Imler Jeffrey R Deschamps Zoltan Beck Carl R Alving Arthur E Jacobson Kenner C Rice Gary R Matyas

An improved synthesis of a haptenic heroin surrogate 1 (6-AmHap) is reported. The intermediate needed for the preparation of 1 was described in the route in the synthesis of 2 (DiAmHap). A scalable procedure was developed to install the C-3 amido group. Using the Boc protectng group in 18 allowed preparation of 1 in an overall yield of 53% from 4 and eliminated the necessity of preparing the di...

Journal: :Journal of immunology 2012
Susan L Baldwin Sylvie Bertholet Valerie A Reese Lance K Ching Steven G Reed Rhea N Coler

An effective protein-based vaccine for tuberculosis will require a safe and effective adjuvant. There are few adjuvants in approved human vaccines, including alum and the oil-in-water-based emulsions MF59 (Novartis Vaccines and Diagnostics), AS03 and AS04 (GlaxoSmithKline Biologics), AF03 (Sanofi), and liposomes (Crucell). When used with pure, defined proteins, both alum and emulsion adjuvants ...

2015
Xingyuan Ling Hai Long Guang Pan Zhinan Chen

ABI PRISM 3100 Genetic Analyzer, a multi-color fluorescence-based DNA analysis system with 16 capillaries operating in parallel, was ideal tool both for DNA sequencing and DNA fragment analysis [1,2]. To demonstrate the effectiveness and reliability of an asymmetric PCR-Based approach (X.Y. Ling, G.M. Zhang, G. Pan, H. Long, Y.H. Cheng, C.Y. Xiang, L. Kang, F. Chen, Z.N. Chen, Preparing long pr...

2014
Sharmila Pejawar-Gaddy James M. Kovacs Dan H. Barouch Bing Chen Darrell J. Irvine

Immunization strategies that elicit antibodies capable of neutralizing diverse virus strains will likely be an important part of a successful vaccine against HIV. However, strategies to promote robust humoral responses against the native intact HIV envelope trimer structure are lacking. We recently developed chemically cross-linked lipid nanocapsules as carriers of molecular adjuvants and encap...

2015
Ethan Poteet Phoebe Lewis Feng Li Sheng Zhang Jianhua Gu Changyi Chen Sam On Ho Thai Do SuMing Chiang Gary Fujii Qizhi Yao Shan Lu

HIV virus-like particles (VLPs) present the HIV envelope protein in its native conformation, providing an ideal vaccine antigen. To enhance the immunogenicity of the VLP vaccine, we sought to improve upon two components; the route of administration and the additional adjuvant. Using HIV VLPs, we evaluated sub-cheek as a novel route of vaccine administration when combined with other conventional...

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