Research work was carried out to describe the kinetics of cell growth, substrate consumption and product formation in batch fermentation of rapamycin using shake flask as well as laboratory-scale fermentor. Fructose was used as the sole carbon source in the fermentation media. Optimization of fermentation parameters and reliable mathematical models were used for the maximum production of rapamy...

Mathematical modeling of anaerobic digestion (AD) is widely acknowledged as a powerful tool to v of the process and to support full-scale plant design, operation and optimization. In this work, a modified version of the IWA-ADM1 model is proposed to simulate the AD of tannery primary sludge (TPS) and fleshing, with special emphasis on the disintegration formulation. Multiple batch tests were pe...

Nutrient availability is one of the major factors regulating marine productivity and phytoplankton community structure. While the response of phytoplankton species to nutrient variation is relatively well known, that of phytoplankton community remains unclear. We question whether phytoplankton community growth rates respond to nutrient concentration in a similar manner to phytoplankton species ...

The study of transcription remains one the centerpieces modern biology with implications in settings from development to metabolism evolution disease. Precision measurements using a host different techniques including fluorescence and sequencing readouts have raised bar for what it means quantitatively understand transcriptional regulation. In particular our understanding simplest genetic circu...

mathematical modeling and simulation of microbial polyhydroxybutyrate (phb) production process is beneficial for optimization, design, and control purposes. in this study a batch model developed by mulchandani et al., [1] was used to simulate the process in matlab environment. it was revealed that the kinetic model parameters were estimated off the optimal or at a local optimal point. therefore...

Repair rather than segregation of damage is the optimal unicellular aging strategy Model equations. In all cases, growth of active protein depends on substrate concentration S following Monod kinetics: (). (1) If repair of damaged protein takes place, the rate of repair is: (). (2) Basic model: damaged protein inert, and not repaired:

An advanced study of a bioreactor system involving aNavier–Stokes basedmodel has been accomplished. The model allows a more realistic impeller induced flow image to be combined with the Monod bioreaction kinetics reported previously. The time-course of gluconic acid production by Aspergillus niger strain is simulated at kinetic conditions proposed in the literature. The simulation is based on (...

Optimization of process variables in the bioconversion of pretreated sugarcane bagasse using cellulase and Saccharomyces cerevisiae by Simultaneous Saccharification and Fermentation (SSF) was investigated in the present study. A 23 five level Central Composite Design (CCD) experiments with central and axial points were used to develop a statistical model for the optimization of process variable...

a mathematical model for commercial naphtha catalytic reformer of tehran refinery was developed. this model includes three sequencing fixed beds of pt/al2o3 catalyst at the steady state condition using detailed kinetic scheme involving 26 pseudo-components connected by a network of 47 reactions, in the range of c6 to c9 hydrocarbons. the reaction network consisted dehydrogenation, hydrogenation...

Modeling and simulation of Polyhydroxybutyrate (PHB) production by Protomonas extorquens in fed-batch culture were conducted in this research. The fed-batch model, developed for this process, employed a kinetic model proposed by other researchers. Several kinetic models were investigated to choose the best model. The criterion for this selection was goodness of fit (δ2). Haldane kinetic model w...