A major advantage of using monoclonal antibodies over polyclonal antisera is the potential availability of large quantities of the specific monoclonal antibody. In general, preparations containing the monoclonal antibody include a hybridoma supernatant, ascites fluid from a mouse inoculated with the hybridoma, and purified monoclonal antibody. Hybridoma supernatants are easy to produce, especia...

To evaluate the effect of intravenous rituximab, a monoclonal antibody to B-cells, on interstitial lung disease, skin fibrosis and arthritis in patients with systemic sclerosis (SSc).

virulence of the opportunistic yeast, candida albieans, involves the interplay of many complex changes including the yeast-hyphae transition, which mainly involves protein changes. cell wall mannoproteins are found to be the main cause of adherence of c. albieans to epithel ial cells in the first step of an infection process. in the present study, cell wall mannoproteins of intact yeast were pu...

Physicians and patients in search of outpatient monoclonal antibody therapies for coronavirus disease 2019 (COVID-19) can turn to a recently launched federal government website enter their zip code.

BACKGROUND This phase I trial was conducted to determine the safety and pharmacokinetics of monoclonal antibody 216, a human monoclonal Immunoglobulin M antibody targeting a linear B-cell lactosamine antigen, administered alone and in combination with vincristine in patients with relapsed or refractory B-cell acute lymphoblastic leukemia, and to preliminarily assess tumor targeting and efficacy...

Capillary zone electrophoresis (CZE) and immuno-subtraction electrophoresis (ISE) were evaluated for ability to detect and immunotype monoclonal proteins, compared with agarose gel electrophoresis (AGE) and immunofixation electrophoresis (IFE), respectively. Six hundred seventeen serum samples were analyzed with CZE and AGE to determine sensitivity and specificity in detecting IFE-confirmed mon...

ObjectiveTo review type 1 hypersensitivity reactions and anaphylaxis to checkpoint inhibitor–monoclonal antibodies its management with drug desensitization.Data SourcesEnglish-language literature on MEDLINE regarding hypersensitivity, anaphylaxis, antibodies.Study SelectionsReferences were selected based relevance, novelty, robustness, applicability.ResultsThere are well-known tissue toxicities...

in recent years, recombinant monoclonal antibodies and their derivatives have emerged as important targeted therapy agents. monoclonal antibodies are ex-tremely difficult to produce. so, the cost of production is very high and many people cannot afford these drugs. in this regard, choosing inexpensive and easy ways to manipulate production systems such as bacterial hosts to reduce the cost of m...

In recent years, there have been significant advancements in cancer treatment, particularly with the use of Monoclonal Antibodies (mAbs). These targeted therapies shown promise managing different types fewer side effects due to their high specificity. They become a predominant category newly developed drugs. antibodies offer diverse mechanisms action and can directly target cells while also boo...