Tracey Day, Cecilia Morgan, Adi Ferrara, and Jim Kublin Welcome to a new edition of the HVTNews, the newsletter of the HIV Vaccine Trials Network. Our newsletter’s mission is to provide timely updates on the science of HIV vaccines, and the science of the HVTN. To that end, this issue features discussions that include innate immunity studies at the HVTN, the possible impact of the RV144 Correla...

As shown in Fig. 1, LCI results with similar impact pathways (e.g. all elementary flows influencing stratospheric ozone concentrations) are grouped into impact categories at midpoint level, also called midpoint categories. A midpoint indicator characterizes the elementary flows and other environmental interventions that contribute to the same impact. The term 'midpoint' expresses the fact that ...

A personalized e-learning service provides learning content to fit learners’ individual differences. Learning achievements are influenced by cognitive as well as non-cognitive factors such as mood, motivation, interest, and personal styles. This paper proposes the Learning Caution Indexes (LCI) to detect aberrant learning patterns. The philosophy behind the LCI is that if any non-cognitive fact...

To understand network dynamics of microcircuits in the neocortex, it is essential to simultaneously record the activity of a large number of neurons . In-vivo two-photon calcium imaging is the only method that allows one to record the activity of a dense neuronal population with single-cell resolution . The method consists in implanting a cranial imaging window, injecting a fluorescent calcium ...

This paper discusses the measurement of poverty and well-being. A historical overview is given of the last fifty years. This is followed by discussion of three groupings of indicators: those measures based primarily on economic well-being; those based on non-economic well-being and composite indicators. It is argued that the choice of indicator should reflect its purpose and that economic measu...

The spatio-temporal variability of trends in vegetation greenness in dryland areas is a well-documented phenomenon in remote sensing studies at global to regional scales. The underlying causes differ, however, and are often not well understood. Here, we analyzed the trends in vegetation greenness for a semi-arid area in northeastern Brazil (NEB) and examined the relationships between those dyna...

This paper explores temporal aspects of control behavior in order to support the design of systems where functions can be allocated flexibly in time. Dynamic Function Scheduling, an extension of Dynamic Function Allocation approaches, highlights the role of temporal information and temporal reasoning in supervisory control decisions. The microworld experiment presented 30 participants with a su...

While general publication practices clearly differ between disciplines, knowledge about scientometric indicators can also greatly vary. The observed heterogeneity in bibliometric knowledge inspired us to define the concept of ‘metric-wiseness’ for researchers. Being metric-wise can lead to an advantage for knowledgeable researchers over uninformed colleagues, even when they are of otherwise equ...

Expression of multiple reporter or effector transgenes in the same cell from a single construct is increasingly necessary in various experimental paradigms. The discovery of short, virus-derived peptide sequences that mediate a ribosome-skipping event enables generation of multiple separate peptide products from one mRNA. Here we describe methods and vectors to facilitate easy production of pol...