نتایج جستجو برای: molecular biophysics
تعداد نتایج: 645260 فیلتر نتایج به سال:
Regulating physical size is an essential problem that biological organisms must solve from the subcellular to the organismal scales, but it is not well understood what physical principles and mechanisms organisms use to sense and regulate their size. Any biophysical size-regulation scheme operates in a noisy environment and must be robust to other cellular dynamics and fluctuations. This work d...
Upon endoplasmic reticulum Ca(2+) store depletion, Orai channels in the plasma membrane are activated directly by endoplasmic reticulum-resident STIM proteins to generate the Ca(2+)-selective, Ca(2+) release-activated Ca(2+) (CRAC) current. After the molecular identification of Orai, a plethora of functional and biochemical studies sought to compare Orai homologs, determine their stoichiometry,...
Department of Cellular and Molecular Pharmacology, Biochemistry and Biophysics, Howard Hughes Medical Institute, University of California San Francisco, California Institute for Quantitative Biomedical Research, San Francisco, CA 94143, USA. Faculty of Life Sciences, University of Manchester, Manchester, M13 9PT, United Kingdom. Present address: Department of Molecular and Cellular Biology, Har...
Molecular Probes provides a full spectrum of fluorophores and haptens for labeling biopolymers and derivatizing low molecular weight molecules. Chapters 1–5 describe the chemical and spectral properties of the reactive reagents we offer, whereas the remainder of this Handbook is primarily devoted to our diverse collection of fluorescent probes and their applications in cell biology, immunology,...
Alejandro Garbino, Ralph J. van Oort, Sayali S. Dixit, Andrew P. Landstrom, Michael J. Ackerman, and Xander H. T. Wehrens Department of Molecular Physiology and Biophysics, Translational Biology and Molecular Medicine Program, Baylor College of Medicine, Houston, Texas; Departments of Molecular Pharmacology & Experimental Therapeutics, Medicine, and Pediatrics/Divisions of Cardiovascular Diseas...
* 1 CUBIC, Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168 Street BB217, New York, NY 10032, USA; 2 Columbia University Center for Computational Biology and Bioinformatics (C2B2), Russ Berrie Pavilion, 1150 St. Nicholas Avenue, New York, NY 10032, USA; 3 North East Structural Genomics Consortium (NESG), Department of Biochemistry and Molecular Biophysics, ...
2 Environment 3 Ruobing Zhang,†,‡,r Eli Rothenberg,‡,§,O,r Gilbert Fruhwirth, Paul D. Simonson, Fangfu Ye, 4 Ido Golding, ,§,^ Tony Ng, || Ward Lopes, ,# and Paul R. Selvin* ,‡ ,§ 5 Center for Biophysics and Computational Biology, Center of Physics of Living Cells, and Physics Department, 6 and University of Illinois at Urbana Champaign, Urbana, Illinois 61801, United States 7 The Richard Dimbl...
KATHY PIEPLES,1 GRACE ARTEAGA,5 R. JOHN SOLARO,5 INGRID GRUPP,2 JOHN N. LORENZ,3 GREG P. BOIVIN,4 GANAPATHY JAGATHEESAN,1 ERIN LABITZKE,1 PIETER P. DETOMBE,5 JOHN P. KONHILAS,5 THOMAS C. IRVING,6 AND DAVID F. WIECZOREK1 1Department of Molecular Genetics, Biochemistry, and Microbiology, 2Department of Pharmacology and Cell Biophysics, 3Department of Molecular and Cellular Physiology, 4Department...
A macromolecular structure, as measured data or as a list of coordinates or even on-screen as a full atomic model, is an extremely complex and confusing object. The underlying rules of how it folds, moves, and interacts as a biological entity are even less evident or intuitive to the human mind. To do science on such molecules, or to relate them usefully to higher levels of biology, we need to ...
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