mog35

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تعداد نتایج: 133 فیلتر نتایج به سال:

Informing and inspiring

2014

Richard M. Ransohoff

This second issue of Neurology® Neuroimmunology & Neuroinflammation incorporates examples of the types of reports that incarnate our mission: to inform and inspire the community of neuroinflammation and neuroimmunology researchers. Tran et al. report a phase I trial of LINGO antibodies, inaugurating clinical development of remyelination therapy for multiple sclerosis (MS), and the attainment of...

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Optic Neuritis, A New Variant of Experimental Encephalomyelitis, A Durable Model for All Seasons, Now In Its Seventieth Year

Journal: :The Journal of Experimental Medicine 2003

Lawrence Steinman

One of the most enduring models of human disease now celebrates the seventieth anniversary of its publication in The Journal of Experimental Medicine . Thomas Rivers, working at the Hospital of the Rockefeller Institute for Medical Research, along with his colleagues D.H. Sprunt and G.P. Berry, submitted the article entitled, “Observations on Attempts to Produce Disseminated Encephalomyelitis i...

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Functional Interleukin-17 Receptor A is Expressed in the Central Nervous System and Upregulated in Experimental Autoimmune Encephalomyelitis

2008

Jayasri Das Sarma Bogoljub Ciric Ryan Marek Sanjoy Sadhukhan Jasmine Shafagh Denise C. Fitzgerald Kenneth S. Shindler A. M. Rostami

Interleukin-17A (IL-17A) is founding member of a novel family of inflammatory cytokines that plays a critical role in the pathogenesis of many autoimmune diseases, including multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). IL17A signals through IL-17RA, which is expressed in most peripheral tissues; however, expression of IL-17RA in the central nerv...

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