Intestinal adenoma development in Apc(Min) mice is influenced by genetic background. We generated a congenic line between the CAST and B6 inbred strains to study the effects of a resistant CAST background in the absence of a major modifier locus, Modifier of Min 1 (Mom1(R)). Progeny from a CAST.B6 Mom1(R/S) x B6 Apc(Min/+) intercross were 110 or 200 days of age and screened for intestinal polyp...

Polydopamine (PDA) prepared in the form of a layer of polymerized dopamine (DA) in a weak alkaline solution has been used as a versatile biomimetic surface modifier as well as a broadly used immobilizing macromolecule. This review mainly discusses the progress of biomaterial surface modification inspired by the participation of PDA in bone tissue engineering. A comparison between PDA-assisted c...

The influence of a minor strontium (Sr) modifier on the microstructures and mechanical properties of 7075 Al alloys was investigated in this paper. The grain size of cast 7075 Al alloys was refined from 157 μm to 115 μm, 108 μm, and 105 μm after adding 0.05 wt. %, 0.1 wt. %, and 0.2 wt. % Sr, respectively. The extruded 7075 Al alloys was refined with different degrees of Sr modifier. The mechan...

with respect to the physical and mechanical limited qualities of bitumen, it benefits from certain specificability in application and its life service. polymers as the most important modifiers of bitumen are applied to it in order to improve its functional efficiency. among various polymers, styrene-butadiene- styrene (sbs) is the best modifier of the bitumen. in this work, sbs polymer as one o...

A combined analysis of enzyme inhibition and activation is presented, based on a rapid equilibrium model assumption in which one molecule of enzyme binds one molecule of substrate (S) and/or one molecule of a modifier X. The modifier acts as activator (essential or non-essential), as inhibitor (total or partial), or has no effect on the reaction rate (v), depending on the values of the equilibr...

STUDY DESIGN The assignment of idiopathic scoliosis curves to the curve types,1-6 to the lumbar spine modifier (A, B, or C), and to the sagittal thoracic modifier (-, N, +), as recently described by Lenke et al, was evaluated by five observers on two occasions. OBJECTIVE To determine the intraobserver and interobserver reliabilities of Lenke's new system for classifying idiopathic scoliosis. ...