Poly(lactic-co-glycolic acid) (PLGA) based nanoparticles have gained increasing attention in delivery applications due to their capability for controlled drug release characteristics, biocompatibility, and tunable mechanical, as well as degradation, properties. However, thorough study is always required while evaluating potential toxicity of the particles from dose dumping, inconsistent release...

Gene delivery holds therapeutic promise for the treatment of neurological diseases and spinal cord injury. Although several studies have investigated the use of non-viral vectors, such as polyethylenimine (PEI), their clinical value is limited by their cytotoxicity. Recently, biodegradable poly (lactide-co-glycolide) (PLGA) nanospheres have been explored as non-viral vectors. Here, we show that...

Biomimetic adsorbent named as PHBBMA was prepared from lipophilic poly-3-hydroxybutyrate (PHB) by a modified double emulsion solvent evaporation method. PHBBMA, characterized by using scanning electron microscope and nitrogen adsorption/desorption measurements, is porous spherical particles. The characterization with the thermal gravimetric analysis and differential scanning calorimetry, 1H nuc...

The present investigation was aimed to formulate and evaluate the gastro-retentive floating microballoons of glipizide using hydrophilic polymers hydroxypropyl methylcellulose (HPMC) and Eudragit RS100 (RS 100) by emulsion solvent evaporation technique. The floating microballoons were evaluated using micromeritic properties, buoyancy, in vitro drug release, scanning electron microscopy and stab...

Poly(D,L-lactic-co-glycolic acid) (PLGA) is an important material used in drug delivery when controlled release is required. The purpose of this research is to design and characterize PLGA microparticles (PLGA MPs) implants for the controlled release of nicardipine hydrochloride (NCH) in vitro. This study used the water-in-oil-in-water (w1/o/w2) double emulsion and solvent diffusion/evaporation...

Purpose: To rationalize the use of surfactants by preparing Salbutamol sulphate microspheres using two types of surfactants, Tween 80 and Span 80 and study their effects on different characteristics of the microspheres. Methods: Microspheres containing Salbutamol sulphate was prepared by emulsion solvent evaporation technique. Infrared Spectroscopy, Differential Scanning Colorimetry and X-Ray D...

The present study was initiated to understand the effect of PLGA concentration, PVA concentration, internal-external phase ratio, homogenization speed, and homogenization time on mean particle size, zeta potential, and percentage drug encapsulation using fractional factorial design. Using PLGA (50-50) as the carrier, hyaluronidase loaded PLGA nanoparticles were prepared using double emulsion so...

Although artificial micromotors have undergone tremendous progress in recent years, their fabrication normally requires complex steps or expensive equipment. In this paper, we report a facile one-step method based on an emulsion solvent evaporation process to fabricate multifunctional micromotors. By simultaneously incorporating various components into an oil-in-water droplet, upon emulsificati...

The aim of the present study was to investigate the morphology and function of a drug eluting metallic porous surface produced by the immobilization of poly lactide-co-glycolide microspheres bearing dexamethasone onto plasma electrolytically oxidized Ti-6Al-7Nb medical alloy. Spheres of 20 microm diameter were produced by an oil-in-water emulsion/solvent evaporation method and thermally immobil...

Aceclofenac was formulated as novel enteric microcapsules for improved delivery to the intestine using the polymer ethyl cellulose as the retardant material. Micro encapsulation of aceclofenac was done to achieve a controlled drug release profile suitable for per oral administration. Aceclofenac was used as core and microcapsules were prepared by an emulsion solvent evaporation method. The prep...