BAG-1 is a family of proteins with diverse activities that range in cultured cells from protection against programmed cell death through to regulation of steroid hormone action. At least three proteins (BAG-1L, BAG-1M and BAG-1) are encoded by the Bag-1 mRNA through the use of alternative translation-initiation sites. To assess the in vivo function of these factors, we have used in situ hybridi...

The aim of this study was to detect the expression of BRCA-1 and BAG-1 in Triple Negative Breast Cancer (TNBC), and analyse the correlation between protein expression and sensitivity to Platinumbased Chemotherapy (PbC). Malignant tissues from 72 TNBC patients who were treated according to the NP and GP programs; then, the relationships between BRCA-1 and BAG-1 protein expression and the surviva...

Identity Other names: BAG-1, HAP, HAP46, RAP46 HGNC (Hugo): BAG1 Location: 9p13.3 DNA/RNA Description Centromere to telomerase orientation; 7 exons. Transcription 5 alternative transcripts; 1079 nucleotides mRNA. Protein Description Three isoforms generated by alternative translation initiation; 50kDa (BAG-1L), 46kDa (BAG-1M) and 36kDa (BAG-1S)(Yang et al., 1998). Each BAG-1 isoform contains a ...

PURPOSE To study the mechanical dynamics between the zonuli-capsular complex and an accommodating intraocular lens mechanics simulator using pharmacological stimulation of the ciliary body in a primate eye. METHODS Following phacoemulsification removal of the lens, force/movement gauges simulating the accommodating intraocular lens mechanics were implanted in 8 primate eyes (4 positioned in-t...

Theriodopteryx ephemeraeformis commonly known as bag worms produce ultrafine silk fibers that are remarkably different than the common domesticated (Bombyx mori) and wild (Saturniidae) silk fibers. Bag worms are considered as pests and commonly infect trees and shrubs. Although it has been known that the cocoons (bags) produced by bag worms are composed of silk, the structure and properties of ...

Intravenous pressure bag Theatre table TECHNiQUE An intravenous fluid pressure bag is placed under the pelvis at the start of the procedure. To protect the patient from direct contact with the bag and the plastic components of the device, the bag is placed under a gel pad. The pump protrudes over a lateral edge of the operating table. Having reached the point when the modified position is requi...

— In this study, we aim to solve the single-view robot self-localization problem by using visual experience across domains. Although the bag-of-words method constitutes a popular approach to single-view localization, it fails badly when it's visual vocabulary is learned and tested in different domains. Further, we are interested in using a cross-domain setting, in which the visual vocabulary is...

Treatment of HER2+ breast cancer with trastuzumab is effective and combination anti-HER2 therapies have demonstrated benefit over monotherapy in the neoadjuvant and metastatic settings. This study investigated the therapeutic potential of targeting the BAG-1 protein co-chaperone in trastuzumab-responsive or -resistant cells. In the METABRIC dataset, BAG-1 mRNA was significantly elevated in HER2...

BACKGROUND BAG-1 (bcl-2 associated athanogene) is a multifunctional protein that protects cells from a wide range of apoptotic stimuli including radiation, hypoxia and chemotherapeutic agents. Overexpression of cytoplasmic BAG-1 has been associated with the increased survival and decreased response to treatment with tamoxifen (TAM) in breast cancer. We attempted to assess the expression of BAG-...