there exists compelling evidence that toll-like receptor 3 (tlr3) agonists can directly affect human cancer cells. the aim of this study was to investigate anti-cancer effects of tlr3 agonist in human breast cell line. we assessed potential effects of poly (a:u) on human breast cell line (mda-mb-231)  on a dose-response and time-course  basis. human breast cell line  mda-mb-231  was treated wit...

Stroke is one of the leading causes death and disability worldwide. However, treatment options for ischemic stroke remain limited. Matrix-metalloproteinases (MMPs) contribute to brain damage during strokes by disrupting blood-brain barrier (BBB) causing edemas. Carnosine, an endogenous dipeptide, was found us others be protective against injury. In this study, we investigated whether carnosine ...

Purpose Failed Back Surgery Syndrome (FBSS) occurs in 10–40% of patients treated surgically due to disk herniation (DH). There are several factors that can cause a predisposition FBSS, but the exact pathomechanism has not been elucidated. The aim this study was investigate Metalloproteinase-2 (MMP-2) and Tissue Inhibitor (TIMP-2) activities homogeneous group FBSS with epidural fibrosis comparis...

Earlier findings reported the anticancer-mediated activities of curcumin-modified compounds Pentagamavunone-1 (PGV-1) and Chemoprevention Curcumin Analog 1.1 (CCA-1.1) with several mechanisms including cell cycle arrest, reactive oxygen species (ROS) production, migration disruption. Our study aims to evaluate antimigratory activity PGV-1 CCA-1.1 on aggressive breast cancer lines (MDA-MB-231 HC...

effects of doxycycline on cx43 distribution and cardiac arrhythmia susceptibility of rats after myocardial infarction abstract: this study aimed to observe the effects of doxycycline (dox) on gap junction remodeling after mi and the susceptibility of rats to cardiac arrhythmia. the proximal left anterior descending coronary artery of rats was ligated to establish a myocardial infarction animal ...

Background: Matrix MetalloProteinases (MMPs) degrade extracellular matrix components to provide normal remodeling and contribute to pathological tissue destruction and cell migration in endometriosis. It is accepted that MMPs are resistant to suppression by progesterone in endometriotic tissues. The physiological effects of progesterone are mediated by its two progesterone receptor (PR) isoform...

The hemopexin-like domain of membrane-type matrix metalloproteinase-1 (MT1-MMP) enables MT1-MMP to form oligomers that facilitate the activation of pro-matrix metalloproteinase-2 (pro-MMP-2) at the cell surface. To investigate the role of the MT1-MMP hemopexin domain in the trafficking of MT1-MMP to the cell surface we have examined the activity of two MT1-MT4-MMP chimaeras in which the hemopex...

Matrix metalloproteinases (MMP) play an important role in pathogenesis of inflammatory bowel disease (IBD). Two known gelatinases, MMP-2 and MMP-9, are upregulated during IBD. Epithelial-derived MMP-9 is an important mediator of tissue injury in colitis, whereas MMP-2 protects against tissue damage and maintains gut barrier function. It has been suggested that developing strategies to block MMP...