OBJECTIVE Multiple myeloma is a plasma cell neoplasm characterized by the accumulation of malignant plasma cells within the bone marrow. This disease remains incurable despite major treatment improvements. However, gene expression profiling of multiple myeloma cells (MMC) may lead to identification of new therapeutic targets. MATERIALS AND METHODS Using Affymetrix microarrays, we identified t...

BACKGROUND The purpose of this paper was to assess the feasibility of Micro-Mobile Compression® (MMC) on lactate clearance following exhaustive exercise and on subsequent exercise performance. METHODS Elite male cyclists were randomized to MMC (n = 8) or passive recovery (control, n = 8). MMC is incorporated into a sandal that intermittently compresses the venous plexus during non-weight bear...

purpose: to assess the efficacy of intraoperative mitomycin c (mmc) during silicone intubation (si) as a substitute for dacryocystorhinostomy (dcr) in nasolacrimal duct (nld) obstruction. methods: in a prospective, randomized, double-blind study, 88 candidates of dcr for nld obstruction were randomly assigned into two groups of si with application of either mmc (0.2 mg/ml for 2 minutes) or plac...

MMC when applied topically or injected subconjunctivally, prevents proliferation of fibroblasts within the subconjunctival space and tenon’s capsule. It also has a lethal effect on vascular endothelial cells. A single application of MMC can cause localized, irreversible inhibition of both fibroblasts and vascular endothelial cells. MMC is estimated to be 100 times more potent than 5-FU in fibro...

PURPOSE To analyze conjunctival cytological features 1 month after pterygium excision using limbo-conjunctival autograft (LCA) with and without intraoperative mitomycin C and to assess tissue short-term evolution in both situations. METHODS Fifty-nine primary nasal pterygia from 59 patients were excised with LCA. Twenty-nine were treated with intraoperative mitomycin C 0.02% (MMC+) and 30 wer...

By Steven D. Vold, MD Isolated from the fungus Streptomyces caespitosus, mitomycin C (MMC) inhibits DNA synthesis, which prevents cells from dividing and growing.1,2 It is this quality that led the FDA to approve MMC for the treatment of advanced stomach and pancreatic cancer in combination with other chemotherapeutic agents. MMC is also currently widely used in ophthalmology, including glaucom...

purpose: to compare the efficacy and safety of topical mitomycin-c (mmc) drops versus subconjunctival 5-fluourouracil (5-fu) injections for management of early bleb failure after trabeculectomy or combined phacoemulsification and trabeculectomy with posterior chamber intraocular lens implantation (pt+pciol). methods: in a comparative study, 37 eyes of 37 patients with impending early bleb failu...

We present an optimizing compiler for the π-calculus that significantly improves the time and space performance of the MMC model checker. MMC exploits the similarity between the manner in which resolution techniques handle variables in a logic program and the manner in which the operational semantics of the π-calculus handles names by representing π-calculus names in MMC as Prolog variables, wi...

BACKGROUND The transesophageal echocardiograhpy (TEE) has been studied worldwide. However, identifying additional factors on top of operator's experience and patient's cooperation which could influence the success of the procedure in unsedated patients with heart disease  is not well documented. METHODS Under the cross-sectional descriptive design, 85 target patients were fulfilling the crite...

BACKGROUND Mitomycin C (MMC) is an antitumor agent that is often administered intravesically to treat bladder cancer. Pharmacologically optimized studies have suggested varying methods to optimize delivery, with drug concentration and solution volume being the main drivers. However, these MMC concentrations (e.g. 2.0 mg/mL) supersede its solubility threshold, raising major concerns of inferior ...