نتایج جستجو برای: mlh1

تعداد نتایج: 1941  

Journal: :Hereditary Cancer in Clinical Practice 2008

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Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2009
Krishan Kumar Hassan Brim Francis Giardiello Duane T Smoot Mehdi Nouraie Edward L Lee Hassan Ashktorab

PURPOSE Colorectal cancer develops through genetic, epigenetic, and environmental events that result in uncontrolled cell proliferation. Colorectal cancer incidence and mortality is higher in African Americans (AA) than in the general population. Here, we carried out a molecular analysis of sporadic colorectal cancer tumors from AAs to investigate possible explanations for the observed disparit...

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Journal: :Journal of medical genetics 2001
A Wagner Y Hendriks E J Meijers-Heijboer W J de Leeuw H Morreau R Hofstra C Tops E Bik A H Bröcker-Vriends C van Der Meer D Lindhout H F Vasen M H Breuning C J Cornelisse C van Krimpen M F Niermeijer A H Zwinderman J Wijnen R Fodde

Hereditary non-polyposis colorectal cancer (HNPCC) is the most common genetic susceptibility syndrome for colorectal cancer. HNPCC is most frequently caused by germline mutations in the DNA mismatch repair (MMR) genes MSH2 and MLH1. Recently, mutations in another MMR gene, MSH6 (also known as GTBP), have also been shown to result in HNPCC. Preliminary data indicate that the phenotype related to...

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Journal: :Cell 2011
Hans Hombauer Christopher S. Campbell Catherine E. Smith Arshad Desai Richard D. Kolodner

DNA mismatch repair (MMR) increases replication fidelity by eliminating mispaired bases resulting from replication errors. In Saccharomyces cerevisiae, mispairs are primarily detected by the Msh2-Msh6 complex and corrected following recruitment of the Mlh1-Pms1 complex. Here, we visualized functional fluorescent versions of Msh2-Msh6 and Mlh1-Pms1 in living cells. We found that the Msh2-Msh6 co...

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Journal: :World journal of gastroenterology 2013
Marisa C Alvarez Juliana C Santos Nathália Maniezzo Marcelo S Ladeira Artur L C da Silva Isabel C A Scaletsky José Pedrazzoli Marcelo L Ribeiro

AIM To evaluate the association between Helicobacter pylori (H. pylori) infection and MLH1 and MGMT methylation and its relationship with microsatellite instability (MSI). METHODS The methylation status of the MLH1 and MGMT promoter region was analysed by methylation specific methylation-polymerase chain reaction (MSP-PCR) in gastric biopsy samples from uninfected or H. pylori-infected childr...

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2015

Despite similar genome sizes, a great variability in recombination rates is observed in mammals. We used antibodies against SYCP3, MLH1 and centromeres to compare crossover frequency, position along chromosome arms and the effect of crossover interference in spermatocytes of 4 species from the family Bovidae ( Bos taurus , 2n = 60, tribe Bovini; Ovis aries , 2n = 54, Capra hircus , 2n = 60 and ...

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2012
E Edwards M Bowman M Walsh J Kirk

Lynch syndrome is an autosomal dominant cancer predisposition syndrome which is caused by a germline mutation in one of four genes, MLH1, MSH2, MSH6 or PMS2. Individuals with a germline mutation in one of these genes are at increased lifetime risk of colon, endometrial, ovarian, small intestine, renal pelvis and ureter. Less commonly patients may develop biliary tract cancers, gastric and pancr...

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Journal: :Cytogenetic and genome research 2015
Jan Fröhlich Miluse Vozdova Svatava Kubickova Halina Cernohorska Hana Sebestova Jiri Rubes

Despite similar genome sizes, a great variability in recombination rates is observed in mammals. We used antibodies against SYCP3, MLH1 and centromeres to compare crossover frequency, position along chromosome arms and the effect of crossover interference in spermatocytes of 4 species from the family Bovidae (Bos taurus, 2n = 60, tribe Bovini; Ovis aries, 2n = 54, Capra hircus, 2n = 60 and Ammo...

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Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 1996
P C Lim D Tester W Cliby S C Ziesmer P C Roche L Hartmann S N Thibodeau K C Podratz R B Jenkins

DNA mismatch repair genes have been reported to play a role in the pathogenesis of hereditary nonpolyposis colorectal cancer (HNPCC). Mutations of DNA mismatch repair genes have accounted for 90% of HNPCC-related colon and endometrial tumors. These mutations have been associated with microsatellite instability (MIN). Because endometrial cancer (EC) is the most common extracolonic malignancy ass...

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Journal: :Polish journal of pathology : official journal of the Polish Society of Pathologists 2010
Anna Bąkiewicz Jacek Michalak Stanisław Sporny

Carcinogenesis is a multistep process resulting from mutations in genes controlling the cellular growth, differentiation, apoptosis, and genome integrity maintenance. We investigated relationships between the PTEN and MLH1 immunoreactivity in the cancer cells and the histological subtypes of endometrial carcinoma as well as the survival times of the affected women. The PTEN and MLH1 protein imm...

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