The identification of a novel β coronavirus, nCoV, as the causative agent of severe respiratory illness in humans originating in Saudi Arabia, Qatar and Jordan has raised concerns about the possibility of a coronavirus pandemic similar to that of SARS-CoV. As a definitive treatment regimen has never been thoroughly evaluated for coronavirus infections, there is an urgent need to rapidly identif...

By the works of Levine [2] and Rolfsen [5], [6], it is known that a local move called a crossing-change is strongly related to the Alexander invariant. In this note, we will consider to what degree the relationship is strong. Let K be a knot, and K the set of knots obtained from a knot K by a single crossing-change. Let MK be the Alexander invariant of a knot K, and MK the set of the Alexander ...

Mesenchymal cells known as myo-/fibroblasts (MFs) are critical immunosuppressors under gut mucosal homeostasis. Expression of immune checkpoint PD-L1 by MFs plays a key role in the control T cell inflammatory responses. In Crohn’s disease (CD), switch their activity from immunosuppressive to pro-inflammatory, where they also Inflammatory Fibroblasts. However, mechanisms responsible for these pa...

Microwave-assisted Suzuki-Miyaura cross-coupling reactions have been employed towards the synthesis of three different MAPKAPK2 (MK2) inhibitors to study accelerated aging in Werner syndrome (WS) cells, including the cross-coupling of a 2-chloroquinoline with a 3-pyridinylboronic acid, the coupling of an aryl bromide with an indolylboronic acid and the reaction of a 3-amino-4-bromopyrazole with...

When modeling cell signaling networks, a balance must be struck between mechanistic detail and ease of interpretation. In this paper we apply a fuzzy logic framework to the analysis of a large, systematic dataset describing the dynamics of cell signaling downstream of TNF, EGF, and insulin receptors in human colon carcinoma cells. Simulations based on fuzzy logic recapitulate most features of t...

Active specific immunotherapy has been implemented in patients with advanced malignant melanoma, utilizing the mouse antiidiotypic (anti-id) monoclonal antibody (mAb) MK2-23 which bears the internal image of high molecular weight-melanoma associated antigen (HMW-MAA). In a previous study, development of anti-HMW-MAA immunity in patients with advanced malignant melanoma immunized with anti-id mA...

Activation of the p38 kinase pathway in immune cells leads to the transcriptional and translational regulation of proinflammatory cytokines. Mitogen-activated protein kinase-activated protein kinase 2 (MK2), a direct downstream substrate of p38 kinase, regulates lipopolysaccharide (LPS)-stimulated tumor necrosis factor (TNF ) and interleukin-6 (IL-6) production through modulating the stability ...

This document describes the design, fabrication and measurement results of the CART Mk2 10 m radio reflector prototype constructed at the Dominion Radio Astrophysical Observatory. Introduction The Composite Applications for Radio Telescopes (CART) project at the Herzberg Institute of Astrophysics’ (HIA) Dominion Radio Astrophysical Observatory (DRAO) in Penticton Canada is an ongoing effort to ...

The effect of polypropylene (PP) on the Seebeck coefficient (S) carbon nanofibers (CNFs) in melt-extruded PP composites filled with up to 5 wt. % CNFs was analyzed this study. as-received present an electrical conductivity ~320 S m?1 and interesting phenomenon showing negative S-values ?5.5 ?VK?1, 10?2 µW/mK2 as power factor (PF). In contrast, PP/CNF showed lower conductivities ~50 m?1, less ?3...