The results of lymphocyte functional studies performed with the peripheral blood mononuclear cells (MNCs) of patient Wa with a non-Sezary T-ceIl leukemia are described. The aggressive clinical course and the distinctive histologic, cytochemical, and cytogenetic features of this T-cell lymphoproliferative disorder are detailed in an accompanying report. Immunologic marker analysis revealed that ...

Parental-type spleen cells or thoracic duct lymphocytes (TDL), 1 when injected under the renal capsules of genetically tolerant F1 hybrid recipients, initiate an inflammatory reaction that results in the local destruction of tissue in the rat (1). Elkins has described many aspects of this local graft-versus-host (GVH) reaction, repeatedly stressing the requirement for hematogenous cells of the ...

In order to utilize the mixed lymphocyte reaction (MLR) as an assay of T-lymphocyte competence, pools of target lymphocytes obtained from different individuals are used to increase the magnitude and decrease the variation of the in vitro response. We evaluated variations in MLR response due to variations in target cell populations. Response increased with an increased target/responder cell r...