In clinical practice, functional mood stability—which can on occasion be achieved with optimum lithium therapy—is the gold standard that both clinicians and patients strive to attain. To facilitate this endeavor, guidelines on lithium therapy have become increasingly sophisticated; they not only provide therapeutic indications and plasma levels with respect to efficacy, but also inform practiti...

Objective: To study the efficacy and safety of Topiramate versus Sodium Valproate for the Treatment of Bipolar Disorder in Adolescents Methodology: One hundred twenty adolescents (aged 12-18) with an admission diagnosis of bipolar I disorder, manic or mixed episode were enrolled from the Adolescent Ward at Ebn-e-Sina Psychiatric Center of Mashhad University. They were assigned to receive 8 week...

conclusion distinct neurochemical and histological structure changes (cortico-striatal-thalamic-cortical cycle) exist in patients with first-episode ocd. 1h-mrs is capable of identifying these changes by assessing metabolic abnormalities. objectives this study aims to use magnetic resonance spectroscopy (mrs) to discover substance-metabolism abnormalities of brain circuits in patients with firs...

RESULTS: Two recipients were euthanized within 2 weeks of DBMT due to neutropenic sepsis and posttransplant lymphoproliferative disorder but both VCAs remained viable up to experimental endpoint. M4515 (full MHC-mismatched recipient) has been off of all immunosuppression for 3 weeks without any evidence of rejection. M3815 (haplomatched) developed mixed chimerism transiently at 6 weeks after DB...

Methods Retrospective cohort study of all patients under IST (corticosteroids, chemotherapy or other immunosuppressive drugs) admitted with infection at a 11-bed mixed ICU, in a tertiary care, university-affiliated hospital, between January 2011 and December 2014. Patients who started IS in the same episode were excluded. MDR pathogen was defined as a pathogen resistant to at least three antibi...

DSM-5 defines psychotic disorders as abnormalities in 1 or more of 5 domains: delusions, hallucinations, disorganized thinking, grossly disorganized or abnormal motor behavior, and negative symptoms. The current psychiatric nosology does not recognize postpartum psychosis as a distinct disorder. DSM-IV-TR allowed clinicians to apply the “with postpartum onset” specifier to brief psychotic disor...

BACKGROUND Lamotrigine has been shown to be an effective treatment for bipolar depression and rapid cycling in placebo-controlled clinical trials. This double-blind, placebo-controlled study was conducted to assess the efficacy and tolerability of lamotrigine and lithium compared with placebo for the prevention of relapse or recurrence of mood episodes in recently manic or hypomanic patients wi...

We herein report the case of a 44-year-old woman who developed protein-losing gastroenteropathy (PLGE) with hypoalbuminemia as the first manifestation of mixed connective tissue disease (MCTD). Albumin leakage from the stomach and intestinal tract was demonstrated by 99mTc-labeled human serum albumin scintigraphy. The patient's response to prednisolone therapy was insufficient; therefore, addit...

Substance abuse can produce symptoms similar to other psychiatric disorders, thus confusing the diagnostic picture. This paper attempts to elucidate how misdiagnosis in bipolar disorder might be explained by the presence of substance abuse comorbidities. The overlap of symptoms, limited information about symptom onset, and inexperienced clinicians can result in the misinterpretation of symptoms...

In an effort to understand how psychotherapy is practiced in the "real world," outpatient claims data were examined to determine the cost of individual and family therapy provided by marital and family therapists, master's nurses, master's social workers, medical doctors, psychologists, or professional counselors. Claims for 490,000 unique persons over 4 years were obtained from CIGNA. Family t...