نتایج جستجو برای: mitochondrial cytopathies

تعداد نتایج: 132410  

Journal: :genetics in the 3rd millennium 0
حسن حسنی کومله hassan hassani kumleh national institute for genetic engineering and biotechnology, tehran, iran غلام حسین ریاضی gholam hossein riazi national institute for genetic engineering and biotechnology, tehran, iran مسعود هوشمند massoud houshmand national institute for genetic engineering and biotechnology, tehran, iran محمد حسین صنعتی mohammad hossein sanati national institute for genetic engineering and biotechnology, tehran, iran کوروش قره گوزلو kourosh gharagozli national institute for genetic engineering and biotechnology, tehran, iran مهدی شفا شریعت پناه mehdi shafa shariat panahi national institute for genetic engineering and biotechnology, tehran, iran

multiple sclerosis (ms) is a demyelinating disease of the central nervous system characterized by morphological hallmarks of inflammation, demyelination and axonal loss. to date, little attention has been paid to the contribution of mitochondrial respiratory chain enzyme activities to ms. in this study, kinetic analysis of mitochondrial respiratory chain complex i enzyme (measured as nadh ferri...

M Amornratanayut N Raungrungsri W Janthasoot

A Thai plant Clitoria macrophylla Wall. was claimed to possess some pharmacological activities. The phytochemical studies reported a rotenoid compound, 6-deoxyclitoriacetal, which exhibits the cytotoxic effect in several cell line experiments. This report was to study the effect of 6-deoxyclitoriacetal on rat liver mitochondria, which may associated to its cytotoxic phenomena. Mitochondrial sus...

M Amornratanayut N Raungrungsri W Janthasoot

A Thai plant Clitoria macrophylla Wall. was claimed to possess some pharmacological activities. The phytochemical studies reported a rotenoid compound, 6-deoxyclitoriacetal, which exhibits the cytotoxic effect in several cell line experiments. This report was to study the effect of 6-deoxyclitoriacetal on rat liver mitochondria, which may associated to its cytotoxic phenomena. Mitochondrial sus...

Journal: :cell journal 0

introduction: a number of maternally inherited mitochondrial diseases with distinct clinical phenotypes have been associated with point mutations in mtdna, all of which result in neurologic or neuromuscular disorders. several studies showed that mutations in the trna genes of mtdna could cause mitochondrial disease due to the decreased synthesis of mitochondrial dna coded proteins. materials an...

Allahveisi A, Ghaffari Novin M Yousefian E

Background: Mitochondria are the most aboudent and small essential organelles found in eukaryotic cells. These are semiautonomous organelles for the production of cellular ATP that through its various biochemical pathways. The primary pathway for ATP production is OXPHOS via the electron transfer chain (ETC) which is encoded by nuclear DNA and mtdna genomes. Mitochondria consist of double stran...

B-acute lymphoblastic leukemia (B-ALL) is the frequent pediatric malignity. Chemotherapy is the most practical approaches to deal with such malignancies. Microtubule-targeted agents are one of the most strategic drugs which formerly use in chemotherapy.Although,colchicine-binding anti-tubulin agents exhibited promising effects in clinical trials, their exact mechanism of action is not fully und...

اقبالی ابراهیم آبادی, منیره, خاتمی, مهری,

Background and purpose: Long QT syndrome is a heart arrhythmia identified by prolongation of the QT interval which is a cause of sudden cardiac death in young individuals. In most cases, abnormalities in heart repolarization are reasons of prolongation of action potential and arrhythmia. The activity of ion channels is sensitive to ATP level, therefore, mitochondrial disorders are considered...

Objective(s): This work aimed to assess the effect of 10 new chromon-3-aldehyde derivatives on changes of mitochondrial function under the conditions of brain ischemia in rats. Materials and Methods: The work was executed on BALB/c male-mice (acute toxicity was evaluated) and male Wistar rats, which were used to model cerebral ischemia b...

Journal: :iranian journal of pharmaceutical research 0
jalal pourahmad faculty of pharmacy, shahid beheshti university of medical sciences, p.o. box 14155-6153, tehran , iran. yassar mortada faculty of pharmacy, shahid beheshti university of medical sciences, p.o. box 14155-6153, tehran , iran. mohammad reza eskandari department of pharmacology and toxicology, school of pharmacy, zanjan university of medical sciences, zanjan, iran. jafar shahraki faculty of pharmacy, shahid beheshti university of medical sciences, p.o. box 14155-6153, tehran, iran.

in this research, we investigated the cytotoxic mechanisms of one of the widely used pharmaceuticals that are regularly associated with the adverse effects on the liver, sometimes leading to acute liver failure, diclofenac. diclofenac liver cytotoxicity was associated with reactive oxygen species (ros) formation and lipid peroxidation which were inhibited by antioxidants and ros scavengers, fer...

Introduction: Diabetic encephalopathy is described as any cognitive and memory impairments and associated with hippocampal degenerative changes, include neurodegenerative process and decreased number of living cell. Mitochondrial Diabetes (MD) appears fallowing activation of mutant mitochondrial DNA and is combination of diabetes and cognitive deficit. In this research we showed the correlation...

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