In normothermic cats under light barbiturate anesthesia, cerebral blood flow was arrested for one hour by intrathoracal occlusion of the innominate, the left subclavian, and both mammary arteries. Recirculation of the brain after ischemia resulted in reactive hyperemia, followed by a decrease of blood flow to about 70% of control (post-ischemic hypoperfusion). During postischemic hypoperfusion,...

In a canine model of global cerebral ischemia, 6 dogs received a saline placebo prior to the event and 5 received 12.5 mg/kg ibuprofen. Cerebral venous outflow from the confluence of the sagittal and transverse sinuses, systolic and diastolic arterial pressure, cardiac output, pH, Paco2, Pao2, and arterial and sagittal sinus thromboxane B2 and 6-keto-PGF1 alpha were measured at intervals up to ...

Migraine has been connected to hypoperfusion and cerebral ischemia in several studies [1,2]. Moreover, increased prevalence of silent white mater changes and even minute cerebral infarcts is reported in migraineurs [1]. Cucchiara and Detre proposed that migraine can cause or result from cerebral ischemia [3]. The basis of their assumption emerged from observations that catheter angiography can ...

Cerebral microangiopathy (CMA) is one of the significant causes depression in elderly. Close associations risk developing with white matter hyperintensity, presence lacunar infarcts, and other markers vascular disease are shown. The available data suggest that various mechanisms, particular, involvement small vessels brain, generalized microvascular endothelial dysfunction, metabolic factors, –...

BACKGROUND AND PURPOSE Vascular pathology and Alzheimer disease (AD) pathology have been shown to coexist in the brains of dementia patients. We investigated how cognitive impairment could be exacerbated in a rat model of combined injury through the interaction of chronic cerebral hypoperfusion and amyloid beta (Aβ) toxicity. METHODS In Wistar rats, chronic cerebral hypoperfusion was modeled ...

Lipid peroxidation reactions during reperfusion after cardiac arrest may contribute to postischemic cerebral hypoperfusion, which in turn can contribute to permanent neurological dysfunction. We designed this study to determine whether the aminosteroid U74006F, a putative inhibitor of lipid peroxidation, mitigates cerebral multifocal hypoperfusion after cardiac arrest. We used our established d...

BACKGROUND The purpose of this manuscript is to present the findings in the largest series of SPECT brain perfusion imaging reported to date for mild or moderate traumatic brain injury. PATIENTS AND METHODS This is a retrospective evaluation of 228 SPECT brain perfusion-imaging studies of patients who suffered mild or moderate traumatic brain injury with or without loss of consciousness (LOC)...

The issue of cerebral vascular pathology is one the most important social problems in modern world, and Russia no exception. Cerebrovascular diseases are distinguished by high prevalence, mortality disability rates. They great importance from a health perspective not only each individual, but total nation. Acute or chronic disorders circulation naturally results atherosclerosis major arteries h...

BACKGROUND AND PURPOSE White matter lesions contribute to cognitive impairment in poststroke patients. The present study was designed to assess the neuroprotective mechanisms of cilostazol, a potent inhibitor of type III phosphodiesterase, through signaling pathways that lead to activation of transcription factor cAMP-responsive element binding protein (CREB) phosphorylation using rat chronic c...

INTRODUCTION Nausea and motion sickness are important operational concerns for aviators and astronauts. Understanding the underlying mechanisms associated with motion sickness may lead to new treatments. The goal of this work was to determine if changes in cerebral blood flow precede the development of nausea in subjects susceptible to motion sickness. METHODS Cerebral flow velocity in the mi...