B2 adrenergic receptor (ADRB2) gene variation could explain differences in bronchodilator response among patients with asthma or identify a subgroup of patients with reduced response. The aim of our research was identified polymorphisms in the ADRB2 gene in Russian asthma pediatric patients (in Perm region). 44 children from 3 to 18 years of age with bronchial asthma were examined. Mild asthma ...

PURPOSE A possible involvement of autoimmune mechanism in the pathogenesis of bronchial asthma has been proposed. Recently, alpha-enolase protein was identified as a major autoantigen recognized by circulating IgG autoantibodies in patients with severe asthma. To evaluate a possible pathogenetic significance of these autoantibodies in severe asthma, isotype (IgG, IgA, IgM, and IgE) and IgG subc...

background: obesity and overweight are accompanied with insulin resistance markers and diagnosed as a metabolic risk factor in prevalence and develop the asthma severity. regardless of biological role of inflammation markers in asthma, the effective mechanisms in relation to obesity and asthma are not fully understood. methods: this study investigates the relationship between insulin resistance...

Background PAR-2, a G-coupled receptor activated by serine proteinases, is widely expressed in the human body and is involved in inflammation. We have shown that PAR-2 activation in the airways plays a pathogenetic role in mouse models of asthma. PAR-2 expression is increased in the epithelium of asthmatic subjects, but its expression on immune and inflammatory cells of asthmatic individuals ha...

Abstract Introduction Obstructive sleep apnea (OSA) and Asthma often coexist. There is some evidence that adults with asthma are more prone to developing OSA than the general population, as well may impact control. Different adults, prevalence equal in boys girls, while puberty has strong influence asthma, especially pubescent girls. The objectives of this study were analyze girls severity prev...

Until the late 1960's there was a remarkable lack of information on the consequences of asthma on arterial oxygenation [1, 2). Since then, it has been known that arterial blood gas abnormalities can range from overt hypoxaemia, usually associated with hypocapnia and respiratory alkalosis, as shown in acute severe asthma, to mild increases in the alveolar-arterial 0 2 tension difference (AaPo,) ...

Introduction Mild intermittent asthma is common in children and viral infections are responsible for the majority of exacerbations. As leukotrienes are potent inflammatory mediators, some studies have shown that Montelukast, a leukotriene receptor antagonist, may be effective on reduction of asthma symptom. To determine whether a short course of Montelukast in asthmatic children with common col...

Remodeling of the airway wall occurs in adults with asthma, and reticular basement membrane (RBM) thickening is pathognomonic of the asthma process. To investigate whether RBM thickening is present in children with difficult asthma and comparable to that seen in adults with asthma, we used light microscopy to measure RBM thickness in plastic-embedded endobronchial biopsy sections from 19 childr...

Asthma is the most common chronic disease of childhood, with asthma exacerbations and wheezing resulting in more than 2 million emergency department visits per year. Symptoms can vary from mild shortness of breath to fatal status asthmaticus. Given the high prevalence of asthma and its potential to progress from mild to moderate to life-threatening, it is vital for emergency clinicians to have ...

Severe childhood asthma is a complicated and heterogeneous disorder with distinct phenotypes. Children with severe asthma have more persistent symptoms despite receiving treatment, more atopy, greater airway obstruction, and more air trapping than those with mild-to-moderate asthma. They also have higher morbidity and substantial airflow limitations that persist throughout adulthood. Identifica...