The question whether symptom-free migraine patients show cognitive impairments compared to matched control subjects is addressed, and also whether migraine patients show transient cognitive impairments induced by an attack. The Neuropsychological Evaluation System (NES2) was administered once in an interictal period and twice within 30 h after different migraine attacks. Since cognitive impairm...

Migraine is a common, recurrent, and disabling primary headache disorder with a genetic component which affects up to 20% of the population. One third of all patients with migraine experiences aura, a focal neurological disturbance that manifests itself as visual, sensitive or motor symptoms preceding the headache. In the pathophysiology of migraine with aura, activation of the trigeminovascula...

Background: Formerly white matter abnormalities in a mixed group of migraine patients with and without aura were shown. Here, we aimed to explore white matter alterations in a homogeneous group of migraineurs with aura and to delineate possible relationships between white matter changes and clinical variables. Methods: Eighteen patients with aura, 25 migraine patients without aura and 28 contro...

Migraine is divided into two forms: migraine without aura, which accounts for around 70-80% of attacks, and migraine with aura, which accounts for around 20-30% of attacks [3]. The pain is mainly unilateral, although it can also occur bilaterally, moderate or severe intensity, it worsens with movement and is associated with nausea and/or vomiting, disturbance of light (photophobia), disturbance...

OBJECTIVES Since 1998, migraine with aura (MA) has been diagnosed according to the operational diagnostic criteria of the International Headache Society (ICHD-1). Here we present the data underlying the new criteria for MA in the ICHD-2 classification. METHODS Sensitivity of the new criteria was tested in patients with MA and specificity in patients with reversible non-aura visual disturbance...

OBJECTIVE Differences between people with and without migraine on various measures of visual perception have been attributed to abnormal cortical processing due to the disease. The aim of the present study was to explore the dynamics of the basic interictal state with regard to the extrastriate, motion-responsive middle temporal area (MT-complex) with functional magnetic resonance imaging (fMRI...

Migraine aura without headache should be considered as a diagnosis in anyone who has recurrent episodes of transient symptoms, especially those that are visual or neurological or involve vertigo. Visual and neurological symptoms due to migraine are not unusual and most commonly occur in older persons with a history of migraine headaches. Migraine aura without headache should be diagnosed only w...

CLINICAL HISTORY A 28-year-old woman has migraine with visual aura about two times per month. The visual aura lasts about 30 minutes and is followed by a hemicranial throbbing headache, which becomes severe associated with nausea, light, and noise sensitivity with a duration of up to 24 hours. Questions.—Would an oral triptan or sumatriptan administered subcutaneously be more effective if given...

BACKGROUND Studies have shown a high prevalence of migraine among narcoleptic patients. HLA-DQB1*0602 and HLA DRB1 alleles are closely associated with narcolepsy. An increase in the HLA-DRB1 allele frequency in patients with visual aura has raised greater awareness of the genetic background in migraine. PURPOSE Since the regions DR and DQ of the HLA are in tightly linkage desiquilibrium we hy...

First identified in 1975, the relationship between migraine and stroke has received considerable attention. Forty years later, solid evidence indicates that those with migraine have a 1.5-fold to 2.5-fold increased risk of stroke. However, the strength of this relationship varies based on the subtypes of migraine (with vs without aura) and stroke (hemorrhagic vs ischemic). While the majority of...