نتایج جستجو برای: midline dose

تعداد نتایج: 320901  

Journal: :Development 1999
R Battye A Stevens J R Jacobs

Guidance of axons towards or away from the midline of the central nervous system during Drosophila embryogenesis reflects a balance of attractive and repulsive cues originating from the midline. Here we demonstrate that Slit, a protein secreted by the midline glial cells provides a repulsive cue for the growth cones of axons and muscle cells. Embryos lacking slit function show a medial collapse...

Journal: :Cell 2000
Srikanth Rajagopalan Valérie Vivancos Emmanuelle Nicolas Barry J. Dickson

On each side of the midline of the Drosophila CNS, axons are organized into a series of parallel pathways. Here we show that the midline repellent Slit, previously identified as a short-range signal that regulates midline crossing, also functions at long range to pattern these longitudinal pathways. In this long-range function, Slit signals through the receptors Robo2 and Robo3. Axons expressin...

Journal: :Neuron 2013
Augusto Escalante Blanca Murillo Cruz Morenilla-Palao Avihu Klar Eloísa Herrera

In bilaterally symmetric organisms, interhemispheric communication is essential for sensory processing and motor coordination. The mechanisms that govern axon midline crossing during development have been well studied, particularly at the spinal cord. However, the molecular program that determines axonal ipsilaterality remains poorly understood. Here, we demonstrate that ipsilateral neurons who...

Journal: :Journal of the Medical Association of Thailand = Chotmaihet thangphaet 2010
Pipat Chiewvit Siri-on Tritakarn Sarun Nanta-aree Suthisak Suthipongchai

OBJECTIVE To evaluate the relationship between the degree of midline shift by Computed Tomography (CT) finding and Glasglow Coma Score (GCS) as a predictive of clinical outcome in patients after head injury. METHOD AND METHOD: The present study was performed by retrospectively reviewing 216 consecutive cases of traumatic head injury admitted to the trauma center in Siriraj Hospital from 1999 un...

Journal: :The Journal of physiology 2005
Peter N Hunt Annette K McCabe Martha M Bosma

Spontaneous, synchronous activity occurs in motor neurones of the embryonic mouse hindbrain at the stage when rhombomeric segmentation disappears (embryonic day 11.5). The mechanisms generating and synchronizing the activity, however, and the extent to which it is widespread in the hindbrain, are unknown. We show here that spontaneous activity is initiated in the midline of the hindbrain, and p...

2011
Yi Zhang Randi Wheatley Eric Fulkerson Amanda Tapp Patricia A. Estes

BACKGROUND The Notch pathway functions repeatedly during the development of the central nervous system in metazoan organisms to control cell fate and regulate cell proliferation and asymmetric cell divisions. Within the Drosophila midline cell lineage, which bisects the two symmetrical halves of the central nervous system, Notch is required for initial cell specification and subsequent differen...

Journal: :Genetics 2008
Patricia Estes Eric Fulkerson Yi Zhang

Functional complexity of the central nervous system (CNS) is reflected by the large number and diversity of genes expressed in its many different cell types. Understanding the control of gene expression within cells of the CNS will help reveal how various neurons and glia develop and function. Midline cells of Drosophila differentiate into glial cells and several types of neurons and also serve...

Journal: :Development 2003
Antoine Bach Yvan Lallemand Marie-Anne Nicola Casto Ramos Luc Mathis Mathilde Maufras Benoît Robert

The dorsal midline of the neural tube has recently emerged as a major signaling center for dorsoventral patterning. Msx genes are expressed at the dorsal midline, although their function at this site remains unknown. Using Msx1(nlacZ) mutant mice, we show that the normal expression domain of Msx1 is interrupted in the pretectum of mutant embryos. Morphological and gene expression data further i...

Journal: :Developmental biology 2014
Joseph C Pearson Stephen T Crews

Transcriptional enhancers integrate information derived from transcription factor binding to control gene expression. One key question concerns the extent of trans- and cis-regulatory variation in how co-expressed genes are controlled. The Drosophila CNS midline cells constitute a group of neurons and glia in which expression changes can be readily characterized during specification and differe...

Journal: :Anesthesia and analgesia 2012
Morito Wada Masato Kitayama Hiroshi Hashimoto Tsuyoshi Kudo Mihoko Kudo Norikazu Takada Kazuyoshi Hirota

A rectus sheath block can provide postoperative analgesia for midline incisions. However, information regarding the pharmacokinetics of local anesthetics used in this block is lacking. In this study, we detail the time course of ropivacaine concentrations after this block. Thirty-nine patients undergoing elective lower abdominal surgery were assigned to 3 groups receiving rectus sheath block wi...

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