The first total chemical synthesis of the site-selective azide-labeled [I66A]HIV-1 protease is described by native chemical ligation. Chemical synthesis of azide-labeled proteins would provide useful protein tools for biochemical, biophysical or medical studies.

The estimation of spectral discontinuities is one of the most common problems in speech concatenative synthesis. This paper introduces a methodology based on analyzing the statistical behaviour of objective measures for natural concatenations. The main goal is defining an automatic process capable of including the most appropriate measures as concatenation cost to generate high quality syntheti...

Combustion synthesis is a special thermophysico-chemical process applied for production of intermetallic compounds. In the present work, a reaction–diffusion numerical model was developed to analyze the combustion synthesis of aluminide intermetallics by self-propagating high-temperature synthesis process. In order to verify the reliability of the numerical model, an experimental setup was desi...

the aim of the present study was to prepare nano-sized calcium fluoride (caf2). calcium fluoride nanoparticles were synthesized by cacl2.6h2o and ammonium fluoride. nanoparticles were synthesized by co-precipitation method. the synthesized nanocrystals were characterized by x-ray diffraction (xrd), fourier transform infrared spectroscopy (ftir), scanning electron microscopy (sem). the crystalli...

two steps synthetic method for the preparation of a novel emulsion stabilizer called poly(ricineoleic acid-b-ethyleneglycol-b-ricineoleic acid) with average mass molecular weight of 7000 daltons is investigated. in the first step, oligoricineoleic acid with average mass molecular weight of 1800 daltons is synthesized (yield 70%). in the second step, the desired copolymer is  synthesized from th...

indole is a nitrogen-containing heterocycle. it is a very important motif in agriculture and pharmacy. many compounds containing indole moiety has been isolated form nature. it is also an important part in natural alkaloids. tryptophan is an amino acid which posses indole. 3-sustituted indoles are the main group of its derivatives. because the wide-spread application of 3-substituted indolic co...

The chemical synthesis of peptides or small proteins is often an important step in many research projects and has stimulated the development of numerous chemical methodologies. The aim of this review is to give a substantial overview of the solid phase methods developed for the production or purification of polypeptides. The solid phase peptide synthesis (SPPS) technique has facilitated conside...

a one-pot synthesis of (s)-(-)-propranolol is reported. zn(no3)2/(+)-tartaric acid catalyzed enantioselective synthesis of (s)-(-)-propranolol via kinetic resolution of key intermediate ?-naphthyl glycidyl ether with high optical and chemical yield.

The synthesis of sound textures, such as rain, wind, or crowds, is an important application for cinema, multimedia creation, games and installations. However, despite the clearly defined requirements of naturalness and flexibility, no automatic method has yet found widespread use. After clarifying the definition, terminology, and usages of sound texture synthesis, we will give an overview of th...

Speech is the important mode of communication and is the current research topic. The concentration is mostly focused on synthesis and analyzing part.Apart of synthesizing, text to speech system is developed.Speech synthesis is an artificial production of human speech.A text to speech system (TTS) is to convert an arbitrary text into speech.In India different languages have been spoken each bein...