BACKGROUND To define the clinical target volume (CTV) for radiotherapy in patients with hepatocellular carcinoma (HCC). METHODS A prospective study was conducted to histologically evaluate the presence and the distance of microscopic extension (ME) for resected HCC on the basis of examination of whole-mount preparations of carcinoma tissue sections. RESULTS A total of 380 whole-mount slides...

Subtype A is one of the rare HIV-1 group M (HIV-1M) lineages that is both widely distributed throughout the world and persists at high frequencies in the Congo Basin (CB), the site where HIV-1M likely originated. This, together with its high degree of diversity suggests that subtype A is amongst the fittest HIV-1M lineages. Here we use a comprehensive set of published near full-length subtype A...

[This corrects the article DOI: 10.1371/journal.pone.0175821.].

We consider a model of brane world gravity in the context of non-conformal non-SUSY matter. In particular we modify the earlier strong coupling solution to the glueball spectrum in an AdS Black Hole by introducing a Randall-Sundrum Planck brane as a UV cut-off. The consequence is a new normalizable zero mass tensor state, which gives rise to an effective Einstein-Hilbert theory of gravity, with...

catalyst toriously ay may catalytic ompartcolloidal building blocks. [ 1–6 ] In the last decade, sev entifi c advances led to the preparation of a diverse anisotropic particles including particles with differen patchy particles, and compartmentalized particles emerging bulk of research has been focused on the tion of multicompartmentalized polymer microand n ticles. [ 6–11 ] Compared to particl...

Computational analyses such as computational fluid dynamics and computational structural dynamics have made major advances towards maturity as engineering tools. Computational aeroelasticity (CAE) is the integration of these disciplines. As CAE matures, it also finds an increasing role in the design and analysis of aerospace vehicles. This paper presents a survey of the current state of CAE wit...

In this issue of Neuron, Giménez-Cassina et al. (2012) show that fuel utilization by neuronal mitochondria, controlled by the Bcl-2 family member BAD, defines response to seizures. Control of K(ATP) channels by mitochondrial metabolism might be a target for antiepileptic therapies.