microRNAs (miRNAs) are promising biomarkers for different pathological models because of their stable and detectable characters in biofluids. Here, we collected urine samples from 5 beagle dogs on the 3th, 6th, 12th day an acute kidney injury (AKI) caused by gentamycin. miRNA levels were measured with high-throughput sequencing results then differentially investigated. Gene Ontology (GO) KEGG p...

MicroRNAs (miRNAs) are a class of small noncoding RNAs of 22 nucleotides which normally function as negative regulators of target mRNA expression at the posttranscriptional level. miRNAs play a role for one or more target genes by suppressing in processes as growth, differentiation, proliferation and cell death. Recent evidence has shown that miRNA mutations or mis-expression correlate with var...

MicroRNAs (miRNAs), the post-transcriptional regulators of gene expression, play key roles in modulating many cellular processes. The changes in the expression profiles of several specific miRNAs affect the interactions between miRNA and their targets in various illnesses, including addiction, HIV, cancer etc. The presence of anti-HIV-1 microRNAs (which regulate the level of infectivity of HIV-...

Rapid and correct diagnosis of acute myocardial infarction (AMI) plays a crucial role in saving patients' life. Although some biomarkers (such as cardiac troponin and creatine kinase) are available for AMI diagnosis so far, there is still a clinical need for novel biomarkers, which can reliably rule in or rule out AMI immediately on admission. Circulating microRNAs (miRNAs) are a potential choi...

The genetic and epigenetic alteration was commonly related to the progression of breast cancer. Epigenetic which comprises DNA methylation microRNA is involved in controlling gene expression cancer cells. change cellular transformation, tumorigenesis, stemness marker were accomplished by this modification. short, non-coding RNAs, are called microRNAs (miRNAs) considered as a master regulator ge...

Introduction MicroRNAs may be implicated in the acquisition of drug resistance chronic myeloid leukemia as they regulate expression not only BCR-ABL1 but also genes associated with activation transfer proteins or essential signaling pathways. Methods To understand impact specifically expressed miRNAs and their target genes, we collected peripheral blood mononuclear cells (PBMC) from patients di...

MicroRNAs (miRNAs) are small non-coding RNAs that function as endogenous silencers of numerous target genes. Hundreds of miRNAs have been identified in the human genome. miRNAs are expressed in a tissue-specific manner and play important roles in cell proliferation, apoptosis, and differentiation. Aberrant expression of miRNAs may also contribute to the development and progression of human hepa...

A growing body of evidence has demonstrated how the development breast cancer (BC) is associated with several environmental risk factors able to induce both genetic and epigenetic modifications, leading neoplastic transformation. In this context, it been shown dietary influence BC cell progression by modulating biomarkers, which microRNAs (miRNAs/miRs) are one most extensively studied. Of note,...

As microRNAs (miRNAs) are important regulators of many biological processes, a series of small RNAomes from plants have been produced in the last decade. However, miRNA data from several groups of plants are still lacking, including some economically important crops. Here microRNAs from Coffea canephora leaves were profiled and 58 unique sequences belonging to 33 families were found, including ...

MicroRNAs are regulators in regulation of broad range of phenotypes. The purple urchin, Strongylocentrotus nudus, is one of the most important marine economic animals that widely distributed in the cold seas along the coasts of eastern pacific area. To date, only 45 microRNAs have been identified in a related species, Strongylocentrotus purpurtus, and there is no report on S. nudus microRNAs. H...