In recent years, the establishment of an ultimate machining method for realizing further ultra precision, ultra smoothness, and ultra micronization is becoming increasingly essential in the manufacture of various microdevices, which are functional structures. This need demand is particularly strong in the areas of object electronics, mechatronics, biology, and medicine. The accuracy sought rang...

The oral bioavailability of BCS (biopharmaceutics classification system) class II drugs with poor solubility and reasonable permeability is limited by the drug dissolution step from drug products. Though prodrug approach is an exciting way of improving the oral bioavailability, it requires extensive studies to establish the safety profile of prodrugs in humans. In view of the increasing market ...

The introduction of the dimension of green chemistry into the assessment of analytical methods should be a natural development trend in chemistry and should coincide with its general policy. Some of the principles of green chemistry—such as prevention of waste generation; safer solvents and auxiliaries; design for energy efficiency; safer chemistry to minimize the potential of chemical accident...

Supercritical fluid technologies (SCFT) represent a recent approach for obtaining pharmaceutical materials in pure physical form and the application of supercritical fluids is a superior alternative to conventional precipitation and extraction processes. Supercritical fluid technology (SCFT) offers exciting opportunities to produce and modify pharmaceutical substances and has the potential to r...

Ticagrelor is a BCS class IV drug that inhibits platelet action by reversibly binding to the P2Y12 receptor. One of major challenges faced (low solubility, low permeability) lower dissolution rate leading bioavailability. The bioavailability marketed formulation ticagrelor approximately 36%. Researchers have come up with various techniques improve II and formulations as an integral part develop...

A new anti-diarrheic drug for humans has been developed based on the physical and chemical properties of the purified natural clinoptilolite NZ. A series of physical, chemical, technological, pharmacological, microbiological, and clinical studies were successfully conducted to meet the requirements of the Cuban Drug Quality Agency. The most important results concerning the properties and biolog...