نتایج جستجو برای: micrometastasis
تعداد نتایج: 567 فیلتر نتایج به سال:
The greatest utility of sentinel lymph node (SLN) assessment is the avoidance of lymph node dissection and related morbidity. Another potential utility is the ability to direct pathologic examination and more sensitive techniques to detect occult micrometastatic disease. New pathologic methods can identify single tumor cells or even genetic material within a single lymph node station, bringing ...
Near-infrared optical imaging is a newer imaging technique that, coupled with sensitive enzymatically specific fluorescent beacons, shows much promise for earlier detection of many cancers and their in situ characterization. On the basis of animal studies demonstrating visualization of micrometastasis-sized tumors and the ability to evaluate therapeutic enzyme inhibition real-time, such imaging...
Angiogenesis-mediated progression of micrometastasis to lethal macrometastasis is the major cause of death in cancer patients. Here, using mouse models of pulmonary metastasis, we identify bone marrow (BM)-derived endothelial progenitor cells (EPCs) as critical regulators of this angiogenic switch. We show that tumors induce expression of the transcription factor Id1 in the EPCs and that suppre...
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